The main characteristic of alcohol use disorder is the consumption of large quantities of
alcohol despite the negative consequences. The transition from the moderate use of alcohol …

In this chapter, we review the effects of global null mutant and overexpressing transgenic
mouse lines on voluntary self-administration of alcohol. We examine approximately 200 …

Background Glutamate signaling within the nucleus accumbens underlies motivated
behavior and is involved in psychiatric disease. Although behavioral sex differences in these …

Alcohol use disorder (AUD) is a chronic debilitating disorder with limited treatment options
and poorly defined pathophysiology. There are substantial genetic and epigenetic …

Background Alcohol binge drinking in humans is thought to increase the risk for alcohol use
disorder (AUD). Unclear is whether drinking patterns (eg, bingelike or stable drinking) …

Binge alcohol drinking during adolescence has long-term effects on the adult brain that alter
brain structure and behaviors, but the underlying mechanisms remain poorly understood …

Rationale Alcohol and nicotine addiction are prevalent conditions that co-occur. Despite the
prevalence of co-use, factors that influence the suppression and enhancement of concurrent …

Protein kinase M zeta, PKMζ, is a brain enriched kinase with a well characterized role in
Long-Term Potentiation (LTP), the activity-dependent strengthening of synapses involved in …

Background Despite the high cost and widespread prevalence of alcohol use disorders,
treatment options are limited, underscoring the need for new, effective medications. Previous …

Alcohol and nicotine are often used together, and there is a high rate of co-occurrence
between alcohol and nicotine addiction. Most animal models studying alcohol and nicotine …