Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …

Aims Phagocytosis is the cellular digestion of extracellular particles, such as pathogens and
dying cells, and is a key element in the evolution of central nervous system (CNS) disorders …

Stroke is a leading cause of disability and mortality, with limited treatment options. After
stroke injury, microglia and CNS‐resident macrophages are rapidly activated and regulate …

Microglial cells are the scions of foetal macrophages which invade the neural tube early
during embryogenesis. The nervous tissue environment instigates the phenotypic …

Neuroinflammation underlies the etiology of multiple neurodegenerative diseases and
stroke. Our understanding of neuroinflammation has evolved in the last few years and major …

Stroke, including ischemic stroke and hemorrhagic stroke can cause massive neuronal
death and disruption of brain structure, which is followed by secondary inflammatory injury …

After stroke, there is a rapid necrosis of all cells in the infarct, followed by a delayed loss of
neurons both in brain areas surrounding the infarct, known as 'selective neuronal loss', and …

The perioperative neurocognitive disorders (PNDs) are one of the most common
complications in elderly patients characterized by various forms of cognitive decline after …

As an integral part of the innate immune system of the brain, resident microglia must react
rapidly to the onset of brain injury and neurological disease. These dynamic cells then …

Senescence-associated alterations in microglia may have profound impact on cerebral
homeostasis and stroke outcomes. However, the lack of a transcriptome-wide comparison …