The spectrin-based membrane skeleton of the humble mammalian erythrocyte has provided
biologists with a set of interacting proteins with diverse roles in organization and survival of …

Axons follow highly stereotyped and reproducible trajectories to their targets. In this review
we address the properties of the first pioneer neurons to grow in the developing nervous …

CRE-binding protein (CREB) belongs to a family of transcription factors that mediates
stimulus-dependent gene expression in neuronal and non-neuronal cells. Here we show …

We have investigated the trafficking of two endogenous axonal membrane proteins, VAMP2
and NgCAM, in order to elucidate the cellular events that underlie their polarization. We …

Chemorepulsion by semaphorins plays a critical role during the development of neuronal
projections. Although semaphorin-induced chemoattraction has been reported in vitro, the …

Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that
are expressed exclusively in the nervous system. The subgroup consists of six members …

Precise wiring of neural circuits is essential for brain connectivity and function. During
development, axons respond to diverse cues present in the extracellular matrix or at the …

NrCAM is a neuronal cell adhesion molecule of the L1 family of immunoglobulin super
family. It plays a wide variety of roles in neural development, including cell proliferation and …

The central nervous system (CNS) of higher organisms is bilaterally‐symmetric. The transfer
of information between the two sides of the nervous system occurs through commissures …

We have determined the crystal structure of the ligand binding fragment of the neural cell
adhesion molecule axonin-1/TAG-1 comprising the first four immunoglobulin (Ig) domains …