A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences

T Tyagi, K Jain, SX Gu, M Qiu, VW Gu… - Nature cardiovascular …, 2022 - nature.com
Platelets have been shown to be associated with pathophysiological processes beyond
thrombosis, demonstrating critical additional roles in homeostatic processes, such as …

Drug-associated thrombocytopenia

T Bakchoul, I Marini - Hematology 2014, the American Society …, 2018 - ashpublications.org
Many drugs have been implicated in drug-induced immune thrombocytopenia (DITP).
Patients with DITP develop a drop in platelet count 5 to 10 days after drug administration …

Thrombosis and thrombocytopenia after ChAdOx1 nCoV-19 vaccination

NH Schultz, IH Sørvoll, AE Michelsen… - New England journal …, 2021 - Mass Medical Soc
We report findings in five patients who presented with venous thrombosis and
thrombocytopenia 7 to 10 days after receiving the first dose of the ChAdOx1 nCoV-19 …

SARS-CoV-2 vaccine and thrombosis: an expert consensus on vaccine-induced immune thrombotic thrombocytopenia

I Elalamy, G Gerotziafas, S Alamowitch… - Thrombosis and …, 2021 - thieme-connect.com
Historically, the vaccination strategies developed in the second half of the 20th century have
facilitated the eradication of infectious diseases. From the onset of COVID-19 pandemic to …

[HTML][HTML] Assessment of immunological anti‐platelet factor 4 antibodies for vaccine‐induced thrombotic thrombocytopenia (VITT) in a large Australian cohort: A …

EJ Favaloro, J Clifford, E Leitinger, M Parker… - Journal of Thrombosis …, 2022 - Elsevier
Background Vaccine‐induced thrombotic thrombocytopenia (VITT) is a rare complication of
adenovirus‐based vaccines aimed to prevent and minimize COVID‐19 and related …

Laboratory testing for heparin-induced thrombocytopenia and vaccine-induced immune thrombotic thrombocytopenia antibodies: a narrative review

TE Warkentin, A Greinacher - Seminars in Thrombosis and …, 2023 - thieme-connect.com
Heparin-induced thrombocytopenia (HIT) and vaccine-induced immune thrombotic
thrombocytopenia (VITT) are highly prothrombotic (thrombosis frequency≥ 50%). Both are …

Diagnosis and management of heparin-induced thrombocytopenia

Y Gruel, E De Maistre, C Pouplard, F Mullier… - … Critical Care & Pain …, 2020 - Elsevier
Heparin-Induced Thrombocytopenia (HIT) is a rare, iatrogenic disease characterised by its
potential severity, mainly related to thrombosis, and by difficulties regarding its diagnosis …

Functional assays in the diagnosis of heparin-induced thrombocytopenia: a review

V Minet, JM Dogné, F Mullier - Molecules, 2017 - mdpi.com
A rapid and accurate diagnosis in patients with suspected heparin-induced
thrombocytopenia (HIT) is essential for patient management but remains challenging …

Detection of platelet-activating antibodies associated with heparin-induced thrombocytopenia

B Tardy, T Lecompte, F Mullier, C Vayne… - Journal of clinical …, 2020 - mdpi.com
Heparin-induced thrombocytopenia (HIT) is a prothrombotic immune drug reaction caused
by platelet-activating antibodies that in most instances recognize platelet factor 4 …

Drug-induced thrombocytopenia: mechanisms and laboratory diagnostics

E Danese, M Montagnana… - … in thrombosis and …, 2020 - thieme-connect.com
Thrombocytopenia is a condition characterized by a decreased number of platelets in
peripheral blood, which can be caused by a myriad of both congenital and acquired …