The copper-catalyzed asymmetric conjugate addition of Grignard reagents to trisubstituted
cyclic enones affords enantioenriched all-carbon quaternary centers with up to 96% ee. The …

Abstract Me3Al, Et3Al, and vinylalane species undergo enantioselective conjugate addition
to a wide range of 2‐or 3‐substituted enones (cyclopent‐2‐enones, cyclohex‐2‐enones, 3 …

Natural sandalwood oil, a unique and valuable ingredient in fine perfumery, has been the
focus of scientific interest for many years. Due to its scarcity and its high price, the search for …

The Robinson annulation is a significant reaction for the synthesis of α, β‐unsaturated
ketone ring including the generation of two C− C bonds. It involves a Michael addition of a …

We report the successful manufacture of several> 50 kg batches of a key intermediate via a
Birch reduction that utilized liquified ammonia as well as lithium metal. With an eye toward …

The features you need: The first total synthesis of lycopodium alkaloid alopecuridine has
been achieved in 13 steps in the longest linear sequence, and its biomimetic conversion into …

The title natural products 2–7 have been prepared by reductive cyclization of the relevant 2-
arylcyclohex-2-en-1-one (eg 20) to the corresponding tetrahydrocarbazole and …

Two sequential palladium-catalyzed reactions are the key steps in a novel synthetic route to
1, 2-dihydro-4 (3H)-carbazolones. The steps are an intermolecular Stille cross-coupling …

An iodine mediated aromatization leading to a one-pot synthesis of iodo-N-arylanilines and
N-arylanilines is reported. This highly regioselective aliphatic–aromatic transformation can …

Chiral 2-cyclohexenones are attractive building blocks for the synthesis of a variety of
natural products. A limited number of naturally occurring optically active cyclohexenones …