Systemic sclerosis
ER Volkmann, K Andréasson, V Smith - The Lancet, 2023 - thelancet.com
Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune
connective-tissue disease. Once considered an untreatable and unpredictable condition …
connective-tissue disease. Once considered an untreatable and unpredictable condition …
Safety and efficacy of rituximab in systemic sclerosis (DESIRES): a double-blind, investigator-initiated, randomised, placebo-controlled trial
Background Systemic sclerosis is a connective tissue disease characterised by multiorgan
fibrosis with an autoimmune background and poor prognosis. Although a few drugs have …
fibrosis with an autoimmune background and poor prognosis. Although a few drugs have …
Tocilizumab prevents progression of early systemic sclerosis–associated interstitial lung disease
D Roofeh, CJF Lin, J Goldin, GH Kim… - Arthritis & …, 2021 - Wiley Online Library
Objective Tocilizumab (TCZ) has demonstrated lung function preservation in 2 randomized
controlled trials in early systemic sclerosis (SSc). This effect has yet to be characterized in …
controlled trials in early systemic sclerosis (SSc). This effect has yet to be characterized in …
Systemic sclerosis–associated interstitial lung disease: How to incorporate two food and drug administration–approved therapies in clinical practice
Systemic sclerosis (SSc; scleroderma) has the highest individual mortality of all rheumatic
diseases, and interstitial lung disease (ILD) is among the leading causes of SSc‐related …
diseases, and interstitial lung disease (ILD) is among the leading causes of SSc‐related …
[HTML][HTML] Expert consensus on the management of systemic sclerosis-associated interstitial lung disease
FF Rahaghi, VM Hsu, RJ Kaner, MD Mayes… - Respiratory …, 2023 - Springer
Abstract Background Systemic sclerosis (SSc) is a rare, complex, connective tissue disorder.
Interstitial lung disease (ILD) is common in SSc, occurring in 35–52% of patients and …
Interstitial lung disease (ILD) is common in SSc, occurring in 35–52% of patients and …
Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis
Inflammation is an important component of fibrosis but immune processes that orchestrate
kidney fibrosis are not well understood. Here we apply single-cell sequencing to a mouse …
kidney fibrosis are not well understood. Here we apply single-cell sequencing to a mouse …
[HTML][HTML] Targeted immunotherapy for autoimmune disease
SM Jung, WU Kim - Immune network, 2022 - ncbi.nlm.nih.gov
In the past few decades, biological drugs and small molecule inhibitors targeting
inflammatory cytokines, immune cells, and intracellular kinases have become the standard …
inflammatory cytokines, immune cells, and intracellular kinases have become the standard …
Treatment of fibrotic interstitial lung disease: current approaches and future directions
Fibrotic interstitial lung disease (ILD) represents a large group of pulmonary disorders that
are often progressive and associated with high morbidity and early mortality. Important …
are often progressive and associated with high morbidity and early mortality. Important …
[HTML][HTML] State-of-the-art evidence in the treatment of systemic sclerosis
JE Pope, CP Denton, SR Johnson… - Nature Reviews …, 2023 - nature.com
Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease with multi-organ
involvement, fibrosis and vasculopathy. Treatment in SSc, including early diffuse cutaneous …
involvement, fibrosis and vasculopathy. Treatment in SSc, including early diffuse cutaneous …