Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

Cell senescence (CS) is at the nexus between aging and associated chronic disorders, and
aging increases the burden of CS in all major metabolic tissues. However, CS is also …

COVID-19 is a trending topic worldwide due to its immense impact on society. Recent trends
have shifted from acute effects towards the long-term morbidity of COVID-19. In this review …

Membrane contact sites emerged in the last decade as key players in the integration,
regulation and transmission of many signals within cells, with critical impact in multiple …

Perturbation of metabolism elicits cellular stress which profoundly modulates the cellular
proteome and thus protein homeostasis (proteostasis). Consequently, changes in the …

Non-specific innate and antigen-specific adaptive immunological memories are vital
evolutionary adaptations that confer long-lasting protection against a wide range of …

Aging is accompanied by impaired mitochondrial function and accumulation of senescent
cells. Mitochondrial dysfunction contributes to senescence by increasing the levels of …

Due to intact reactive oxygen species homeostasis and glucose metabolism, C57BL/6NRj
mice are especially suitable to study cellular alterations in metabolism. We applied Nuclear …

Senescence of adipose precursor cells (APC) impairs adipogenesis, contributes to the age‐
related subcutaneous adipose tissue (SAT) dysfunction, and increases risk of type 2 …

The transcription factor HOXA5, from the HOX gene family, has long been studied due to its
critical role in physiological activities in normal cells, such as organ development and body …