[HTML][HTML] The world of protein acetylation
Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
Spotlight on protein N-terminal acetylation
N-terminal acetylation (Nt-acetylation) is a widespread protein modification among
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …
Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases
Gene-disruptive mutations contribute to the biology of neurodevelopmental disorders
(NDDs), but most of the related pathogenic genes are not known. We sequenced 208 …
(NDDs), but most of the related pathogenic genes are not known. We sequenced 208 …
Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases
Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
First things first: vital protein marks by N-terminal acetyltransferases
N-terminal (Nt) acetylation is known to be a highly abundant co-translational protein
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …
Characterization of histone acylations links chromatin modifications with metabolism
Over the last decade, numerous histone acyl post-translational modifications (acyl-PTMs)
have been discovered, of which the functional significance is still under intense study. Here …
have been discovered, of which the functional significance is still under intense study. Here …
N‐terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects
The vast majority of eukaryotic proteins are N‐terminally modified by one or more
processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include …
processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include …
NATs at a glance
Most proteins receive an acetyl group at the N terminus while in their nascency as the result
of modification by co-translationally acting N-terminal acetyltransferases (NATs). The N …
of modification by co-translationally acting N-terminal acetyltransferases (NATs). The N …
N-terminal protein modifications: Bringing back into play the ribosome
C Giglione, S Fieulaine, T Meinnel - Biochimie, 2015 - Elsevier
N-terminal protein modifications correspond to the first modifications which in principle any
protein may undergo, before translation is completed by the ribosome. This class of …
protein may undergo, before translation is completed by the ribosome. This class of …
Protein N-terminal acetylation: structural basis, mechanism, versatility, and regulation
S Deng, R Marmorstein - Trends in biochemical sciences, 2021 - cell.com
N-terminal acetylation (NTA) is one of the most widespread protein modifications, which
occurs on most eukaryotic proteins, but is significantly less common on bacterial and …
occurs on most eukaryotic proteins, but is significantly less common on bacterial and …