Understanding the neuronal synapse and challenges associated with the mitochondrial dysfunction in mild cognitive impairment and Alzheimer's disease

H Verma, P Gangwar, A Yadav, B Yadav, R Rao… - Mitochondrion, 2023 - Elsevier
Synaptic mitochondria are crucial for maintaining synaptic activity due to their high energy
requirements, substantial calcium (Ca 2+) fluctuation, and neurotransmitter release at the …

[HTML][HTML] Targeting autophagy in Alzheimer's disease: Animal models and mechanisms

XW Zhang, XX Zhu, DS Tang, JH Lu - Zoological research, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder that
leads to cognitive impairment and memory loss. Emerging evidence suggests that …

An in-silico investigation based on molecular simulations of novel and potential brain-penetrant GluN2B NMDA receptor antagonists as anti-stroke therapeutic agents

M El Fadili, M Er-Rajy, W Ali Eltayb, M Kara… - Journal of …, 2024 - Taylor & Francis
GluN2B-induced activation of NMDA receptors plays a key function in central nervous
system (CNS) disorders, including Parkinson, Alzheimer, and stroke, as it is strongly …

[HTML][HTML] P-coumaric acid ameliorates Aβ25–35-induced brain damage in mice by modulating gut microbiota and serum metabolites

B Cao, M Zeng, F Hao, Z Hao, Z Zhang, X Liang… - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease for which there is a
lack of effective therapeutic drugs. There is great potential for natural products to be used in …

[HTML][HTML] Exploring the therapeutic potential of natural compounds for Alzheimer's disease: mechanisms of action and pharmacological properties

J Liu, T Li, G Zhong, Y Pan, M Gao, S Su… - Biomedicine & …, 2023 - Elsevier
Alzheimer's Disease (AD) is a global public health priority characterized by high mortality
rates in adults and an increasing prevalence in aging populations worldwide. Despite …

Raddeanin A isolated from Anemone raddeana Regel improves pathological and cognitive deficits of the mice model of Alzheimer's disease by targeting β …

MH Liu, Y Tang, LQ Qu, LL Song, HH Lo, RL Zhang… - Phytomedicine, 2024 - Elsevier
Background Raddeanin A is a triterpenoid isolated from Anemone raddeana Regel. It
exhibits a broad spectrum of biological activities such as anti-tumor and anti-inflammatory …

Advances in natural polysaccharides in Alzheimer's disease and Parkinson's disease: Insights from the brain-gut axis

Y Feng, F Hao - Trends in Food Science & Technology, 2024 - Elsevier
Background Due to the rapid increase in aging population, there has been a rise in cases of
neurodegenerative diseases (NDs), which is a major challenge for human health …

Navigating the Maze of Alzheimer's Disease by Exploring BACE1: Discovery, Current Scenario, and Future Prospects

F Iram, M Shahid, J Ansari, GM Ashraf… - Ageing Research …, 2024 - Elsevier
Alzheimer's disease (AD) is a chronic neurological condition that has become a leading
cause of cognitive decline in elder individuals. Hardly any effective medication has been …

Neurocognitive Characteristics of Subjective Cognitive Decline and Its Association with Objective Cognition, Negative Emotion, and Sleep Quality in Chinese Elderly

Y Wu, Z Mao, F Cui, J Fan, Z Yuan… - … Disease and Treatment, 2023 - Taylor & Francis
Background and Purpose Subjective cognitive decline (SCD) is recognized as a preclinical
indicator of Alzheimer's disease (AD), and this stage provides a valuable time window for …

[HTML][HTML] Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies

J Zhang, Y Zhang, J Wang, Y Xia, J Zhang… - Signal Transduction and …, 2024 - nature.com
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …