Leukotrienes (LTs) are lipid mediators derived from the 5-lipoxygenase pathway of
arachidonate metabolism. Though best known for their role in asthma, they have broad …

The ability to regulate inflammatory pathways and host defense mechanisms is critical for
maintaining homeostasis and responding to infections and tissue injury. While unbalanced …

Resolvin E1 (RvE1) is a lipid mediator derived from ω3 polyunsaturated fatty acids that
exerts potent antiinflammatory roles in several murine models. The antiinflammatory …

Subverting the host immune response to inhibit inflammation is a key virulence strategy of
Yersinia pestis. The inflammatory cascade is tightly controlled via the sequential action of …

Leukocyte reduced NADP (NADPH) oxidase plays a key role in host defense and immune
regulation. Genetic defects in NADPH oxidase result in chronic granulomatous disease …

Invasive fungal infections are life-threatening, and neutrophils are vital cells of the innate
immune system that defend against them. The role of LTA4H-LTB4-BLT1 axis in regulation …

Leishmaniasis is a neglected tropical disease affecting millions of individuals worldwide.
P2X7 receptor has been linked to the elimination of Leishmania amazonensis. Biological …

In the last few months, the coronavirus disease 2019 (COVID-19) pandemic has affected
millions of people worldwide and has provoked an exceptional effort from the scientific …

Poorly controlled diabetes leads to comorbidities and enhanced susceptibility to infections.
While the immune components involved in wound healing in diabetes have been studied …

Objectives To investigate the regulation of inflammatory and osteoclastogenic signaling by 5-
lipoxygenase (5-LO) in apical periodontitis induced by oral contamination of dental root …