Sarm1-dependent axon degeneration: Nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities
Axons are an essential component of the nervous system, and axon degeneration is an
early feature of many neurodegenerative disorders. The NAD+ metabolome plays an …
early feature of many neurodegenerative disorders. The NAD+ metabolome plays an …
Augustus Waller's foresight realized: SARM1 in peripheral neuropathies
S Geisler - Current Opinion in Neurobiology, 2024 - Elsevier
Peripheral neuropathy is a common neurodegenerative condition characterized by
numbness, tingling, pain, and weakness that frequently starts in the distal limbs. Arising from …
numbness, tingling, pain, and weakness that frequently starts in the distal limbs. Arising from …
Neuroinflammation-mediated white matter injury in Parkinson's disease and potential therapeutic strategies targeting NLRP3 inflammasome
L Xiao, M Wang, Y Shi, X Huang, W Zhang… - International …, 2024 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disease in the
world, severely affecting the quality of life of patients. Recent studies have shown that white …
world, severely affecting the quality of life of patients. Recent studies have shown that white …
Structural characterization of TIR-domain signalosomes through a combination of structural biology approaches
The TIR (Toll/interleukin-1 receptor) domain represents a vital structural element shared by
proteins with roles in immunity signalling pathways across phyla (from humans and plants to …
proteins with roles in immunity signalling pathways across phyla (from humans and plants to …
The Role of NMNAT2/SARM1 in Neuropathy Development
O Tarasiuk, L Molteni, A Malacrida, G Nicolini - Biology, 2024 - mdpi.com
Simple Summary Chemotherapy-induced peripheral neuropathy (CIPN) is a common side
effect of various cancer chemotherapy treatments, often leading to dose reduction or …
effect of various cancer chemotherapy treatments, often leading to dose reduction or …