A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences
Platelets have been shown to be associated with pathophysiological processes beyond
thrombosis, demonstrating critical additional roles in homeostatic processes, such as …
thrombosis, demonstrating critical additional roles in homeostatic processes, such as …
Viscoelastic hemostatic assays: moving from the laboratory to the site of care—a review of established and emerging technologies
J Hartmann, M Murphy, JD Dias - Diagnostics, 2020 - mdpi.com
Viscoelastic-based techniques to evaluate whole blood hemostasis have advanced
substantially since they were first developed over 70 years ago but are still based upon the …
substantially since they were first developed over 70 years ago but are still based upon the …
Live-cell super-resolved PAINT imaging of piconewton cellular traction forces
Despite the vital role of mechanical forces in biology, it still remains a challenge to image
cellular force with sub-100-nm resolution. Here, we present tension points accumulation for …
cellular force with sub-100-nm resolution. Here, we present tension points accumulation for …
Transcatheter aortic valve implantation represents an anti-inflammatory therapy via reduction of shear stress–induced, piezo-1–mediated monocyte activation
S Baratchi, MTK Zaldivia, M Wallert, J Loseff-Silver… - Circulation, 2020 - Am Heart Assoc
Background: Aortic valve stenosis is an increasingly prevalent degenerative and
inflammatory disease. Transcatheter aortic valve implantation (TAVI) has revolutionized its …
inflammatory disease. Transcatheter aortic valve implantation (TAVI) has revolutionized its …
Detection of cellular traction forces via the force-triggered Cas12a-mediated catalytic cleavage of a fluorogenic reporter strand
Molecular forces generated by cell receptors are infrequent and transient, and hence difficult
to detect. Here we report an assay that leverages the CRISPR-associated protein 12a …
to detect. Here we report an assay that leverages the CRISPR-associated protein 12a …
Mechanically triggered hybridization chain reaction
Cells transmit piconewton forces to receptors to mediate processes such as migration and
immune recognition. A major challenge in quantifying such forces is the sparsity of cell …
immune recognition. A major challenge in quantifying such forces is the sparsity of cell …
Reduced platelet forces underlie impaired hemostasis in mouse models of MYH9-related disease
MYH9-related disease patients with mutations in the contractile protein nonmuscle myosin
heavy chain IIA display, among others, macrothrombocytopenia and a mild-to-moderate …
heavy chain IIA display, among others, macrothrombocytopenia and a mild-to-moderate …
Hemodynamic analysis for stenosis microfluidic model of thrombosis with refined computational fluid dynamics simulation
Disturbed blood flow has been increasingly recognized for its critical role in platelet
aggregation and thrombosis. Microfluidics with hump shaped contractions have been …
aggregation and thrombosis. Microfluidics with hump shaped contractions have been …
Novel Movable Typing for Personalized Vein‐Chips in Large Scale: Recapitulate Patient‐Specific Virchow's Triad and its Contribution to Cerebral Venous Sinus …
Abstract The Vein‐Chip recapitulates CVST Virchow's triad and enables systematic
characterization of venous thrombogenesis with respect to fibrin formation and platelet …
characterization of venous thrombogenesis with respect to fibrin formation and platelet …
Alterations in platelet behavior after major trauma: adaptive or maladaptive?
Platelets are damage sentinels of the intravascular compartment, initiating and coordinating
the primary response to tissue injury. Severe trauma and hemorrhage induce profound …
the primary response to tissue injury. Severe trauma and hemorrhage induce profound …