Polyploidy (or whole-genome duplication) is the condition of having more than two basic
sets of chromosomes. Polyploidization is well tolerated in many species and can lead to …

The hallmark of most cardiac diseases is the progressive loss of cardiomyocytes. In the
perinatal period, cardiomyocytes still proliferate, and the heart shows the capacity to …

Aims Sarcomeric gene mutations frequently underlie hypertrophic cardiomyopathy (HCM), a
prevalent and complex condition leading to left ventricle thickening and heart dysfunction …

We present a unifying theory to explain cancer recurrence, therapeutic resistance, and
lethality. The basis of this theory is the formation of simultaneously polyploid and aneuploid …

The imprinted oncofetal long non-coding RNA (lncRNA) H19 is expressed in the embryo,
down-regulated at birth and then reappears in tumors. Its role in tumor initiation and …

A characteristic cellular feature of the mammalian liver is the progressive polyploidization of
the hepatocytes, where individual cells acquire more than two sets of chromosomes …

DNA replication during cell proliferation is 'vertical'copying, which reproduces an initial
amount of genetic information. Polyploidy, which results from whole-genome duplication, is …

The great apes (chimpanzees, bonobos, gorillas, and orangutans) are our closest relatives.
Despite the many similarities, there are significant differences in aging among apes …

Polyploidy (alias whole genome amplification) refers to organisms containing more than two
basic sets of chromosomes. Polyploidy was first observed in plants more than a century ago …

The fundamental understanding of how Cancer initiates, persists and then progresses is
evolving. High-resolution technologies, including single-cell mutation and gene expression …