Mycobacterium tuberculosis (Mtb), the etiological agent of human tuberculosis (TB), has
plagued humans for thousands of years. TB still remains a major public health problem in …

The major causative agent of tuberculosis (TB), ie, Mycobacterium tuberculosis (Mtb), has
developed mechanisms to evade host defense responses and persist within host cells for …

The autophagy pathway is an essential facet of the innate immune response, capable of
rapidly targeting intracellular bacteria. However, the initial signaling regulating autophagy …

The integrity of the interferon (IFN)-γ circuit is necessary to mount an effective immune
response to intra-macrophagic pathogens, especially Mycobacteria. Inherited monogenic …

In recent years, Candida glabrata has emerged as a clinically important pathogen causing
invasive infections and death. This review highlights the main virulence factors of this fungus …

NLRC3, a member of the NLR family, has been reported as a negative regulator of
inflammatory signaling pathways in innate immune cells. However, the direct role of NLRC3 …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), has infected
over 1.7 billion people worldwide and causes 1.4 million deaths annually. Recently, genome …

Macrophages are large mononuclear phagocytic cells that play a vital role in the immune
response. They are present in all body tissues with extremely heterogeneous and plastic …

The innate immune system is the first line of defense protecting the hosts against invading
pathogens. Mud crab (Scylla paramamosain) is widely distributed in China and Indo-west …

Purpose Identifying of host-directed targets and molecular markers of immune response for
tuberculosis (TB) immunotherapy is urgent and meaningful. Previous studies have …