The proteasome is a large multi-subunit protease responsible for the degradation and
removal of oxidized, misfolded, and polyubiquitinated proteins. The proteasome plays …

Numerous studies have supported the idea that de novo protein synthesis is critical for
synaptic plasticity and normal long-term memory formation. This requirement for protein …

Long-term memory (LTM) formation requires transient changes in the activity of intracellular
signaling cascades that are thought to regulate new gene transcription and de novo protein …

Memory consolidation involves transcriptional control of genes in neurons to stabilize a
newly formed memory. Following retrieval, a once consolidated memory destabilizes and …

CaMKII and Protein Kinase A (PKA) are thought to be critical for synaptic plasticity and
memory formation through their regulation of protein synthesis. Consistent with this …

Accumulation of pathological tau in synapses has been identified as an early event in
Alzheimer's disease (AD) and correlates with cognitive decline in patients with AD. Tau is a …

The honeybee (Apis mellifera) has long served as an invertebrate model organism for
reward learning and memory research. Its capacity for learning and memory formation is …

The honey bee is of paramount importance to humans in both agricultural and ecological
settings. Honey bee colonies have suffered from increased attrition in recent years …

Numerous studies have suggested a role for ubiquitin–proteasome-mediated protein
degradation in learning-dependent synaptic plasticity; however, very little is known about …

The activity of the epigenetic writers DNA methyltransferases (Dnmts) after olfactory reward
conditioning is important for both stimulus-specific long-term memory (LTM) formation and …