[HTML][HTML] The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology
A Rutsch, JB Kantsjö, F Ronchi - Frontiers in immunology, 2020 - frontiersin.org
The human microbiota has a fundamental role in host physiology and pathology. Gut
microbial alteration, also known as dysbiosis, is a condition associated not only with …
microbial alteration, also known as dysbiosis, is a condition associated not only with …
Brain borders at the central stage of neuroimmunology
J Rustenhoven, J Kipnis - Nature, 2022 - nature.com
The concept of immune privilege suggests that the central nervous system is isolated from
the immune system. However, recent studies have highlighted the borders of the central …
the immune system. However, recent studies have highlighted the borders of the central …
[HTML][HTML] Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study
C Wang, D Zhu, D Zhang, X Zuo, L Yao, T Liu, X Ge… - BMC psychiatry, 2023 - Springer
Background Complex immune-brain interactions that affect neural development, survival
and function might have causal and therapeutic implications for psychiatric illnesses …
and function might have causal and therapeutic implications for psychiatric illnesses …
[HTML][HTML] Gut microbiota, leaky gut, and autoimmune diseases
A Christovich, XM Luo - Frontiers in immunology, 2022 - frontiersin.org
With the rising prevalence of autoimmune diseases, the role of the environment, specifically
the gut microbiota, in disease development has grown to be a major area of study. Recent …
the gut microbiota, in disease development has grown to be a major area of study. Recent …
CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson's disease
GP Williams, AM Schonhoff, A Jurkuvenaite… - Brain, 2021 - academic.oup.com
Abstract α-Synuclein, a key pathological component of Parkinson's disease, has been
implicated in the activation of the innate and adaptive immune system. This immune …
implicated in the activation of the innate and adaptive immune system. This immune …
Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation
MJC Jordão, R Sankowski, SM Brendecke, Sagar… - Science, 2019 - science.org
INTRODUCTION Under homeostasis, the central nervous system (CNS) hosts microglia
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune …
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune …
[HTML][HTML] Reactive astrocytes in neurodegenerative diseases
K Li, J Li, J Zheng, S Qin - Aging and disease, 2019 - ncbi.nlm.nih.gov
Astrocytes, the largest and most numerous glial cells in the central nervous system (CNS),
play a variety of important roles in regulating homeostasis, increasing synaptic plasticity and …
play a variety of important roles in regulating homeostasis, increasing synaptic plasticity and …
Progressive multiple sclerosis: from pathogenic mechanisms to treatment
J Correale, MI Gaitán, MC Ysrraelit, MP Fiol - Brain, 2017 - academic.oup.com
During the past decades, better understanding of relapsing-remitting multiple sclerosis
disease mechanisms have led to the development of several disease-modifying therapies …
disease mechanisms have led to the development of several disease-modifying therapies …
Regulatory T cells in the treatment of disease
Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving …
patients with systemic or organ-specific autoimmune diseases or those receiving …
T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
Abstract CD4+ T helper (Th) cells are critical for proper immune cell homeostasis and host
defense, but are also major contributors to pathology of autoimmune and inflammatory …
defense, but are also major contributors to pathology of autoimmune and inflammatory …