Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The
treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy …

HIV-1 has evolved a plethora of strategies to overcome the cytoskeletal barrier (ie, actin and
intermediate filaments (AFs and IFs) and microtubules (MTs)) to achieve the viral cycle. HIV …

Novel indazole and benzimidazole analogues were designed and synthesized as tubulin
inhibitors with potent antiproliferative activities. Among them, compound 12b exhibited the …

Abstract Structurally diverse indole-3-pyrazole-5-carboxamide analogues (10-29) were
designed, synthesized, and evaluated for their antiproliferative activity against three cancer …

Extensive preclinical studies have shown that colchicine-binding site inhibitors (CBSIs) are
promising drug candidates for cancer therapy. Although numerous CBSIs were generated …

A series of acridine and quinoline derivatives were designed and synthesized based on our
previous work as novel tubulin inhibitors targeting the colchicine binding site. Among them …

A new series of acrylic acid and acrylate ester derivatives as modified analogs of tubulin
polymerization inhibitors were designed and synthesized. The antiproliferative activity of the …

Microtubules are pivotal in diverse cellular functions encompassing cell signaling,
morphology, intracellular trafficking, and cell mitosis/division. They are validated targets for …

A novel series of diphenylamine derivatives were designed and synthesized, and their
biological activities were evaluated. The anti-proliferative activities of the derivatives were …

Abstract Novel 4, 6-pyrimidine analogues were designed and synthesized as colchicine
binding site inhibitors (CBSIs) with potent antiproliferative activities. Among them, compound …