Alkaloids are a large cluster of molecules found in Mother Nature all over the world. They
are all secondary compounds and collection of miscellaneous elements and biomolecules …

Prostate cancer (PCa) is the second most common malignancy among men worldwide.
Although early-stage disease is curable, advanced stage PCa is mostly incurable and …

Epithelial-to-mesenchymal transition (EMT) is an essential mechanism for development and
wound healing, but in cancer it also mediates the progression and spread of aggressive …

A promising hydrazide based small molecule lead as a potent and selective histone
deacetylase 3 (HDAC3) inhibitor has been developed from a small series of synthesized …

Prostate cancer is the second leading cause of cancer-related death in men. Two classic
cancer hallmarks are a metabolic switch from oxidative phosphorylation (OxPhos) to …

Abstract Dual-targeting anticancer agents 4–29 are designed by combining the structural
features of purine-type microtubule-disrupting compounds and HDAC inhibitors. A library of …

DNA is packaged in an octamer of histones, forming chromatin, a complex of DNA and
proteins. The structural matrix of a chromosome, chromatin and its changes are now …

Podophyllotoxin (PT), a lignan compound from the roots and rhizomes of Podophyllum
peltatum, has diverse pharmacological activities including anticancer effect in several types …

Epigenetic changes in genomics provide phenotypic modification without DNA sequence
alteration. This study shows that benzoic acid, a common food additive and known histone …

Colorectal cancer (CRC) continues to demonstrate high incidence and mortality rates,
emphasizing that implementing strategic measures for prevention and treatment is crucial …