DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at
thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S …

DNA replication must be tightly regulated to ensure that the genome is accurately duplicated
during each cell cycle. When these regulatory mechanisms fail, replicative stress and DNA …

The initiation of DNA synthesis is governed by the licensing of replication origins, which
consists of assembling a pre-replication complex (pre-RC) on origins during late M-and G1 …

Lysosome-associated membrane protein type 2A (LAMP2A) is a key protein in the
chaperone-mediated autophagy (CMA) pathway. LAMP2A helps in lysosomal uptake of …

Eukaryotic DNA replication is a highly conserved process; the proteins and sequence of
events that replicate animal genomes are remarkably similar to those that replicate yeast …

Objective This study aimed to explore whether the regulatory effect of miR-21 on α-synuclein
expression in neurons is a potential mechanism by which geniopside (GP) protects the …

Ubiquitin is a 76‐amino acid protein whose conjugation to protein targets is a form of post‐
translational modification. Protein ubiquitylation is characterized by the covalent attachment …

Nearly a century ago, cell biologists postulated that the chromosomal aberrations blighting
cancer cells might be caused by a mysterious organelle—the centrosome—that had only …

A dividing cell has to duplicate its DNA precisely once during the cell cycle to preserve
genome integrity avoiding the accumulation of genetic aberrations that promote diseases …

Abstract The Greatwall/Ensa/PP2A-B55 pathway is essential for controlling mitotic substrate
phosphorylation and mitotic entry. Here, we investigate the effect of the knockdown of the …