DNA replication origin activation in space and time
M Fragkos, O Ganier, P Coulombe… - Nature reviews Molecular …, 2015 - nature.com
DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at
thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S …
thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S …
DNA replication and oncogene-induced replicative stress
SA Hills, JFX Diffley - Current biology, 2014 - cell.com
DNA replication must be tightly regulated to ensure that the genome is accurately duplicated
during each cell cycle. When these regulatory mechanisms fail, replicative stress and DNA …
during each cell cycle. When these regulatory mechanisms fail, replicative stress and DNA …
The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells
M Tardat, J Brustel, O Kirsh, C Lefevbre… - Nature cell …, 2010 - nature.com
The initiation of DNA synthesis is governed by the licensing of replication origins, which
consists of assembling a pre-replication complex (pre-RC) on origins during late M-and G1 …
consists of assembling a pre-replication complex (pre-RC) on origins during late M-and G1 …
LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy
T Saha - Autophagy, 2012 - Taylor & Francis
Lysosome-associated membrane protein type 2A (LAMP2A) is a key protein in the
chaperone-mediated autophagy (CMA) pathway. LAMP2A helps in lysosomal uptake of …
chaperone-mediated autophagy (CMA) pathway. LAMP2A helps in lysosomal uptake of …
Regulating the licensing of DNA replication origins in metazoa
Eukaryotic DNA replication is a highly conserved process; the proteins and sequence of
events that replicate animal genomes are remarkably similar to those that replicate yeast …
events that replicate animal genomes are remarkably similar to those that replicate yeast …
Geniposide reduces α-synuclein by blocking microRNA-21/lysosome-associated membrane protein 2A interaction in Parkinson disease models
C Su, X Yang, J Lou - Brain research, 2016 - Elsevier
Objective This study aimed to explore whether the regulatory effect of miR-21 on α-synuclein
expression in neurons is a potential mechanism by which geniopside (GP) protects the …
expression in neurons is a potential mechanism by which geniopside (GP) protects the …
Protein monoubiquitylation: targets and diverse functions
T Nakagawa, K Nakayama - Genes to Cells, 2015 - Wiley Online Library
Ubiquitin is a 76‐amino acid protein whose conjugation to protein targets is a form of post‐
translational modification. Protein ubiquitylation is characterized by the covalent attachment …
translational modification. Protein ubiquitylation is characterized by the covalent attachment …
Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy
Nearly a century ago, cell biologists postulated that the chromosomal aberrations blighting
cancer cells might be caused by a mysterious organelle—the centrosome—that had only …
cancer cells might be caused by a mysterious organelle—the centrosome—that had only …
DNA replication and cancer: From dysfunctional replication origin activities to therapeutic opportunities
AS Boyer, D Walter, CS Sørensen - Seminars in cancer biology, 2016 - Elsevier
A dividing cell has to duplicate its DNA precisely once during the cell cycle to preserve
genome integrity avoiding the accumulation of genetic aberrations that promote diseases …
genome integrity avoiding the accumulation of genetic aberrations that promote diseases …
Ensa controls S-phase length by modulating Treslin levels
S Charrasse, A Gharbi-Ayachi, A Burgess… - Nature …, 2017 - nature.com
Abstract The Greatwall/Ensa/PP2A-B55 pathway is essential for controlling mitotic substrate
phosphorylation and mitotic entry. Here, we investigate the effect of the knockdown of the …
phosphorylation and mitotic entry. Here, we investigate the effect of the knockdown of the …