MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Chronic lymphocytic leukemia (CLL) accounts for the vast majority of cases of leukemia.
Patients of advanced age are more likely to develop the condition, which has a highly varied …

Chronic lymphocytic leukemia (CLL) is characterized by the existence of subsets of patients
with (quasi) identical, stereotyped B-cell receptor (BcR) immunoglobulins. Patients in certain …

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia among the adults in
the Western World. CLL (and the corresponding nodal entity small lymphocytic lymphoma …

The discovery of almost identical or 'stereotyped'B-cell receptor immunoglobulins (BcR IG)
among unrelated patients with chronic lymphocytic leukemia (CLL) cemented the idea of …

Pivotal studies from the 1990s offered the first pieces of evidence for the role of
immunoglobulin (IG) receptors and antigen stimulation in the natural history of chronic …

Cell-autonomous B-cell receptor (BcR)-mediated signalling is a hallmark feature of the
neoplastic B lymphocytes in chronic lymphocytic leukaemia (CLL). Here we elucidate the …

B cell receptor (BCR) signaling is a central pathway promoting the survival and proliferation
of normal and malignant B cells. Chronic lymphocytic leukemia (CLL) arises from mature B …

The nuclear factor-κB (NF-κB) pathway is constitutively activated in chronic lymphocytic
leukemia (CLL) patients, and hence plays a major role in disease development and …

Chronic lymphocytic leukemia (CLL) is a malignancy of mature B cells driven by B-cell
receptor (BCR) signaling and activated primarily in the lymph node. The Bruton's tyrosine …