Preclinical studies of the T cell growth factor activity of IL-2 resulted in this cytokine
becoming the first immunotherapy to be approved nearly 30 years ago by the US Food and …

Coronavirus disease 2019 (COVID-19) has swept the world, unlike any other pandemic in
the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; …

The immune system plays a critical role in our health. No other component of human
physiology plays a decisive role in as diverse an array of maladies, from deadly diseases …

Depletion of regulatory T (TReg) cells in otherwise healthy individuals leads to multi-organ
autoimmune disease and inflammation. This indicates that in a normal immune system …

Interleukin-2 (IL-2) exerts crucial functions during immune homeostasis via its effects on
regulatory T (Treg) cells, and the optimizing and fine-tuning of effector lymphocyte …

Interleukin-2 (IL-2) regulates key aspects of CD8 T cell biology–signaling through distinct
pathways IL-2 triggers critical metabolic and transcriptional changes that lead to a spectrum …

Dendritic cells (DCs) play a pivotal role in initiating antigen-specific tumor immunity.
However, the abnormal function of DCs owing to the immunosuppressive tumor …

Abstract Modified interleukin-2 (IL-2) formulations are being tested in cancer patients.
However, IL-2 immunotherapy damages IL-2 receptor (IL-2R)-positive endothelial cells and …

Immunotherapy has emerged as a highly promising approach in the treatment of epithelial
ovarian cancer (EOC). Immune checkpoint blockade (ICB) therapy, PARP inhibitors …

Interleukin-2 (IL-2) immunotherapy is an attractive approach in treating advanced cancer.
However, by binding to its IL-2 receptor α (CD25) subunit, IL-2 exerts unwanted effects …