Research conducted in the past 15 years has yielded crucial insights that are reshaping our
understanding of the systems physiology of branched-chain amino acid (BCAA) metabolism …

The circadian system, that is ubiquitous across species, generates∼ 24 h rhythms in
virtually all biological processes, and allows them to anticipate and adapt to the 24 h …

The military lifestyle often includes continuous operations whether in training or deployed
environments. These stressful environments present unique challenges for service members …

Insulin receptors are highly expressed in the heart and vasculature. Insulin signaling
regulates cardiac growth, survival, substrate uptake, utilization, and mitochondrial …

Electrical activity in the heart exhibits 24-hour rhythmicity, and potentially fatal arrhythmias
are more likely to occur at specific times of day. Here, we demonstrate that circadian clocks …

Circadian regulation of transcriptional processes has a broad impact on cell metabolism.
Here, we compared the diurnal transcriptome of human skeletal muscle conducted on serial …

Essentially all biological processes fluctuate over the course of the day, observed at cellular
(eg, transcription, translation, and signaling), organ (eg, contractility and metabolism), and …

The heart is a highly metabolic organ that uses multiple energy sources to meet its demand
for ATP production. Diurnal feeding–fasting cycles result in fluctuations in substrate …

Brain and muscle arnt-like protein 1 (Bmal1) is a crucial transcription factor, regulating
circadian rhythm and involved in multiple heart diseases. However, it is unknown whether …

Essentially all biological processes fluctuate over the course of the day, manifesting as time-
of-day-dependent variations with regards to the way in which organ systems respond to …