Clinical prospect of mesenchymal stromal/stem cell-derived extracellular vesicles in kidney disease: Challenges and the way forward

M Kosanović, B Milutinović, TJ Kutzner, Y Mouloud… - Pharmaceutics, 2023 - mdpi.com
Kidney disease is a growing public health problem worldwide, including both acute and
chronic forms. Existing therapies for kidney disease target various pathogenic mechanisms; …

Extracellular vesicles for therapeutic nucleic acid delivery: loading strategies and challenges

A Oshchepkova, M Zenkova, V Vlassov - International Journal of …, 2023 - mdpi.com
Extracellular vesicles (EVs) are membrane vesicles released into the extracellular milieu by
cells of various origins. They contain different biological cargoes, protecting them from …

Plant-derived extracellular vesicles as a delivery platform for RNA-based vaccine: feasibility study of an oral and intranasal SARS-CoV-2 vaccine

MAC Pomatto, C Gai, F Negro, L Massari… - Pharmaceutics, 2023 - mdpi.com
Plant-derived extracellular vesicles (EVs) may represent a platform for the delivery of RNA-
based vaccines, exploiting their natural membrane envelope to protect and deliver nucleic …

Intrinsic factors behind long‐COVID: I. Prevalence of the extracellular vesicles

YA El‐Maradny, A Rubio‐Casillas… - Journal of Cellular …, 2023 - Wiley Online Library
It can be argued that the severity of COVID‐19 has decreased in many countries. This could
be a result of the broad coverage of the population by vaccination campaigns, which often …

Genomic communication via circulating extracellular vesicles and long-term health consequences of COVID-19

S Nair, E Nova-Lamperti, G Labarca… - Journal of Translational …, 2023 - Springer
COVID-19 continues to affect an unprecedented number of people with the emergence of
new variants posing a serious challenge to global health. There is an expansion of …

[HTML][HTML] Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes …

YON Lopez, A Iliuk, A Casu, A Parikh, JS Smith… - Diabetes Research and …, 2023 - Elsevier
Recent studies suggest that extracellular vesicles (EVs) play a role in the pathogenesis of
SARS-CoV-2 infection and the severity of COVID-19. However, their role in the interaction …

CD66b+/CD68+ circulating extracellular vesicles, lactate dehydrogenase and neutrophil‐to‐lymphocyte ratio can differentiate coronavirus disease 2019 severity …

R Suades, MF Greco, P Prieto, T Padró… - Journal of …, 2024 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) has been a major public health burden. We
hypothesised that circulating extracellular vesicles (cEVs), key players in health and …

Extracellular Vesicles and Their Role in Lung Infections

S Hambo, H Harb - International Journal of Molecular Sciences, 2023 - mdpi.com
Lung infections are one of the most common causes of death and morbidity worldwide. Both
bacterial and viral lung infections cause a vast number of infections with varying severities …

Edible plant-derived extracellular vesicles for oral mRNA vaccine delivery

C Gai, MAC Pomatto, MC Deregibus, M Dieci, A Piga… - Vaccines, 2024 - mdpi.com
Nucleic acid delivery through extracellular vesicles (EVs) is a well-preserved evolutionary
mechanism in all life kingdoms including eukaryotes, prokaryotes, and plants. EVs naturally …

Extracellular vesicles containing SARS‐CoV‐2 proteins are associated with multi‐organ dysfunction and worse outcomes in patients with severe COVID‐19

D de Miguel‐Perez… - Journal of …, 2024 - Wiley Online Library
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes coronavirus
disease 2019 (COVID‐19) and has been related to more than 7 million deaths globally since …