Although a critical role of adaptive immune system has been confirmed in driving local and
systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying …

Regulatory T lymphocytes are essential to maintain homeostasis of the immune system,
limiting the magnitude of effector responses and allowing the establishment of …

Obesity is accompanied by chronic, low-grade inflammation of adipose tissue, which
promotes insulin resistance and type-2 diabetes. These findings raise the question of how …

Abstract Both Foxp3+ CD4+ regulatory T cells (Treg cells) and local immune responses in
nonlymphoid tissues have long been recognized as important elements of a well …

Myeloid-derived suppressor cells (MDSCs) are heterogenous populations of immature
myeloid progenitor cells with immunoregulatory function. MDSCs play critical roles in …

The effects of galectin-9 on a mouse collagen-induced arthritis (CIA) model were assessed
to clarify whether galectin-9 suppresses CIA by regulating T cell immune responses …

Environmental factors and host genetics interact to control the gut microbiota, which may
have a role in the development of obesity and insulin resistance. TLR2-deficient mice, under …

Rheumatoid arthritis is a multisystemic auto-inflammatory disease affecting up to 1% of the
population and leading to the destruction of the joints. Evidence exists for the involvement of …

Autoimmune diseases affect over 4% of the world's population. Treatments are generally
palliative or use broad spectrum immunosuppressants to reduce symptoms and disease …

We previously demonstrated the suppressive effects of regulatory T cells (Treg cells) on
osteoclast differentiation in vitro. In this article, we show that blood markers of bone …