Stem cells perform many different functions, each of which requires specific metabolic
adaptations. Over the past decades, studies of pluripotent and tissue stem cells have …

Organoids and stem-cell-based embryo models (SEMs) are imperfect organ or embryo
representations that explore a much larger space of possible forms, or morphospace …

The prevailing dogma for morphological patterning in developing organisms argues that the
combined inputs of transcription factor networks and signalling morphogens alone generate …

Gastrulation is a key milestone in the development of an organism. It is a period of cell
proliferation and coordinated cellular rearrangement, that creates an outline of the body …

Patterning and growth are fundamental features of embryonic development that must be
tightly coordinated. To understand how metabolism impacts early mesoderm development …

Extraembryonic tissues have pivotal roles in morphogenesis and patterning of the early
mammalian embryo. Developmental programmes mediated through signalling pathways …

The question of how metabolism impacts development is seeing a renaissance [,]. How
metabolism exerts instructive signaling functions is one of the central issues that need to be …

The field of developmental metabolism is experiencing a technological revolution that is
opening entirely new fields of inquiry. Advances in metabolomics, small-molecule sensors …

In recent years, metabolism has re-emerged as an active effector of physiological changes
rather than a housekeeping process in development. Embryogenesis is underpinned by …

Whole-mount 3D imaging at the cellular scale is a powerful tool for exploring the complex
processes of organoid morphogenesis, as it allows examining tissue architecture, cell types …