Tolerance and resistance of microbial biofilms

O Ciofu, C Moser, PØ Jensen, N Høiby - Nature Reviews Microbiology, 2022 - nature.com
Chronic infections caused by microbial biofilms represent an important clinical challenge.
The recalcitrance of microbial biofilms to antimicrobials and to the immune system is a major …

Gradients and consequences of heterogeneity in biofilms

J Jo, A Price-Whelan, LEP Dietrich - Nature Reviews Microbiology, 2022 - nature.com
Historically, appreciation for the roles of resource gradients in biology has fluctuated
inversely to the popularity of genetic mechanisms. Nevertheless, in microbiology specifically …

Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis

E Rossi, R La Rosa, JA Bartell, RL Marvig… - Nature Reviews …, 2021 - nature.com
Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

Biofilm dispersion

KP Rumbaugh, K Sauer - Nature Reviews Microbiology, 2020 - nature.com
The formation of microbial biofilms enables single planktonic cells to assume a multicellular
mode of growth. During dispersion, the final step of the biofilm life cycle, single cells egress …

Spatial transcriptomics of planktonic and sessile bacterial populations at single-cell resolution

D Dar, N Dar, L Cai, DK Newman - Science, 2021 - science.org
INTRODUCTION Microbial populations display heterogeneous gene expression profiles that
result in phenotypic differences between individual bacteria. This diversity can allow …

Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis

RL Marvig, LM Sommer, S Molin, HK Johansen - Nature genetics, 2015 - nature.com
Little is known about how within-host evolution compares between genotypically different
strains of the same pathogenic species. We sequenced the whole genomes of 474 …

Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms

KT Schiessl, F Hu, J Jo, SZ Nazia, B Wang… - Nature …, 2019 - nature.com
Antibiotic efficacy can be antagonized by bioactive metabolites and other drugs present at
infection sites. Pseudomonas aeruginosa, a common cause of biofilm-based infections …

BacArena: Individual-based metabolic modeling of heterogeneous microbes in complex communities

E Bauer, J Zimmermann, F Baldini… - PLoS computational …, 2017 - journals.plos.org
Recent advances focusing on the metabolic interactions within and between cellular
populations have emphasized the importance of microbial communities for human health …

Microbial translocation and microbiome dysbiosis in HIV-associated immune activation

AS Zevin, L McKinnon, A Burgener… - Current Opinion in HIV …, 2016 - journals.lww.com
Microbial translocation and microbiome dysbiosis in HIV-asso... : Current Opinion in HIV and
AIDS Microbial translocation and microbiome dysbiosis in HIV-associated immune activation …

[图书][B] Practical handbook of microbiology

LH Green, E Goldman - 2021 - books.google.com
Practical Handbook of Microbiology, 4th edition provides basic, clear and concise
knowledge and practical information about working with microorganisms. Useful to anyone …