Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …

Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels
forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to …

To elucidate the genetics of coronary artery disease (CAD) in the Japanese population, we
conducted a large-scale genome-wide association study of 168,228 individuals of Japanese …

Arterial occlusive disease is the leading cause of death in Western countries. Core
contemporary therapies for this disease include angioplasties, stents, endarterectomies and …

Rationale: The gene encoding TCF21 (transcription factor 21) has been linked to coronary
artery disease risk by human genome-wide association studies in multiple racial ethnic …

Background: Mural cells in ascending aortic aneurysms undergo phenotypic changes that
promote extracellular matrix destruction and structural weakening. To explore this biology …

Transforming growth factor beta (TGFβ) is named for the function it was originally discovered
to perform-transformation of normal cells into aggressively growing malignant cells. It …

In contrast with the heart, the adult mammalian vasculature retains significant remodelling
capacity, dysregulation of which is implicated in disease development. In particular, vascular …

Sex differences in coronary artery disease (CAD) presentation, risk factors and prognosis
have been widely studied. Similarly, studies on atherosclerosis have shown prominent sex …

Coronary artery disease (CAD) is characterized by atherosclerotic plaque formation in the
arterial wall. CAD progression involves complex interactions and phenotypic plasticity …