Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi
Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …
expression representing an attractive and validated target for antibiotics. Two well-known …
Corallopyronin A: antimicrobial discovery to preclinical development
AK Krome, T Becker, S Kehraus, A Schiefer… - Natural product …, 2022 - pubs.rsc.org
Covering: August 1984 up to January 2022 Worldwide, increasing morbidity and mortality
due to antibiotic-resistant microbial infections has been observed. Therefore, better …
due to antibiotic-resistant microbial infections has been observed. Therefore, better …
M. tuberculosis Transcription Machinery: A Review on the Mycobacterial RNA Polymerase and Drug Discovery Efforts
Mycobacterium tuberculosis (MTB) is the main source of tuberculosis (TB), one of the oldest
known diseases in the human population. Despite the drug discovery efforts of past …
known diseases in the human population. Despite the drug discovery efforts of past …
Fighting against Clostridioides difficile infection: Current medications
M Quan, X Zhang, Q Fang, X Lv, X Wang… - International Journal of …, 2024 - Elsevier
Clostridioides difficile (formerly Clostridium difficile) has been regarded as an" urgent threat"
and a significant global health problem, as life-threatening diarrhea and refractory …
and a significant global health problem, as life-threatening diarrhea and refractory …
[PDF][PDF] History, Current Situation, and Future Perspectives on Antibiotics and Antibiotic Resistance
Antibiotics are the most crucial drugs for fighting bacterial infection, widely used to treat and
prevent such diseases. Even though these are used against bacterial infections, some …
prevent such diseases. Even though these are used against bacterial infections, some …
PAHs as environmental pollutants and their neurotoxic effects
P Xu, B Liu, H Chen, H Wang, X Guo, J Yuan - … and Physiology Part C …, 2024 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs), which are widely present in incompletely
combusted air particulate matter< 2.5 μm (PM2. 5), tobacco and other organic materials, can …
combusted air particulate matter< 2.5 μm (PM2. 5), tobacco and other organic materials, can …
Establishment of a gnotobiotic pig model of Clostridioides difficile infection and disease
C Nyblade, V Parreno, P Zhou, C Hensley, V Oakes… - Gut Pathogens, 2022 - Springer
Clostridioides difficile (C. difficile) is a gram-positive, spore-forming, anaerobic bacterium
known to be the most common cause of hospital-acquired and antibiotic-associated …
known to be the most common cause of hospital-acquired and antibiotic-associated …
Clostridioides difficile Modifies its Aromatic Compound Metabolism in Response to Amidochelocardin-Induced Membrane Stress
M Brauer, SK Hotop, M Wurster, J Herrmann… - Msphere, 2022 - Am Soc Microbiol
Amidochelocardin is a broad-spectrum antibiotic with activity against many Gram-positive
and Gram-negative bacteria. According to recent data, the antibiotic effect of this atypical …
and Gram-negative bacteria. According to recent data, the antibiotic effect of this atypical …
[PDF][PDF] Актуальные международные и национальные клинические рекомендации по профилактике, диагностике и лечению инфекции Clostridioides difficile у …
МС Журавлева, СИ Ситкин, ИГ Бакулин… - Инфекционные …, 2023 - researchgate.net
Clostridioides difficile является наиболее частой причиной антибиотик-
ассоциированной диареи как у стационарных, так и у амбулаторных пациентов, а …
ассоциированной диареи как у стационарных, так и у амбулаторных пациентов, а …
Screening and the Industry of Myxopyronin B Antibiotic from Different Soil Environments in Egypt
M Kassab - 2024 - preprints.org
Background: Across the world, antibiotic resistance is a grave problem. To address this
issue, it is necessary to investigate new antibiotic sources. Aim of the study: Egypt's diverse …
issue, it is necessary to investigate new antibiotic sources. Aim of the study: Egypt's diverse …