The nematode Caenorhabditis elegans has emerged as an important animal model in
various fields including neurobiology, developmental biology, and genetics. Characteristics …

Werner syndrome protein (WRN) is one of a family of five human RecQ helicases implicated
in the maintenance of genome stability. The conserved RecQ family also includes RecQ1 …

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature
aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase …

Homologous recombination (HR) is an important conserved process for DNA repair and
ensures maintenance of genome integrity. Inappropriate HR causes gross chromosomal …

This article describes the fabrication of a microfluidic device for the liquid culture of many
individual nematode worms (Caenorhabditis elegans) in separate chambers. Each chamber …

Temperature is a key factor for determining the lifespan of both poikilotherms and
homeotherms. It is believed that animals live longer at lower body temperatures. However …

Homologous recombination and nonhomologous end joining (NHEJ) are important DNA
double-strand break repair pathways in many organisms. C. elegans strains harboring …

Background Caenorhabditis elegans is an important model for the study of DNA damage
and repair related processes such as aging, neurodegeneration, and carcinogenesis …

The nematode Caenorhabditis elegans is a key model system for experimental research on
the genetic regulation of aging, and has paved the way towards many important discoveries …

Telomeres protect the ends of eukaryotic chromosomes from being recognized and
processed as double strand breaks. In most organisms, telomeric DNA is highly repetitive …