The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

This article reviews the molecular structure, expression pattern, physiological function,
pathological roles and molecular mechanisms of Twist1 in development, genetic disease …

Chromatin structure creates barriers for each step in eukaryotic transcription. Here we
discuss how the activities of two major classes of chromatin-modifying complexes, ATP …

DOT1 was originally identified as a gene affecting telomeric silencing in S. cerevisiae. We
now find that Dot1p methylates histone H3 on lysine 79, which maps to the top and bottom of …

Chromatin is a highly dynamic structure that imparts structural organization to the genome
and regulates the gene expression underneath. The decade long research in deciphering …

▪ Abstract It has been a long-standing challenge to decipher the principles that enable cells
to both organize their genomes into compact chromatin and ensure that the genetic …

Transcription regulation through chromatin compaction and decompaction is regulated
through various chromatin-remodeling complexes such as nucleosome remodeling and …

The Mi-2/nucleosome remodeling and deacetylase (NuRD) complex is an abundant
deacetylase complex with a broad cellular and tissue distribution. It is unique in that it …

Methylation of cytosines within the CpG dinucleotide by DNA methyltransferases is involved
in regulating transcription and chromatin structure, controlling the spread of parasitic …

The epithelial-mesenchymal transition (EMT) converts epithelial tumor cells into invasive
and metastatic cancer cells, leading to mortality in cancer patients. Although TWIST is a …