Various features, components, and functions of the immune system present daily variations.
Immunocompetent cell counts and cytokine levels present variations according to the time of …

Stress often occurs during toxicity studies. The perception of sensory stimuli as stressful
primarily results in catecholamine release and activation of the hypothalamic–pituitary …

Leukocyte trafficking between blood and tissues is an essential function of the immune
system that facilitates humoral and cellular immune responses. Within tissues, leukocytes …

The number of leukocytes circulating in blood in mammals is under circadian control (ie,∼
24h). We summarize here latest findings on the mechanisms governing leukocyte migration …

Circadian rhythms control almost all aspects of physiology and behavior, allowing temporal
synchrony of these processes between each other, as well as with the external environment …

The importance of a neuroinflammatory response to the development and maintenance of
inflammatory and neuropathic pain have been highlighted in recent years. Inflammatory …

Development of inflammatory diseases, such as metabolic syndrome and cancer, is
prevalent in individuals that encounter continuous disruption of their internal clock. Further …

Breast-milk contains a potent mixture of diverse components, such as the non-protein
nitrogen fraction which includes nucleotides, whose variation in levels is evident throughout …

Dim light at night (dLAN) has become a pervasive part of the modern world, and growing
evidence shows its association with increased health risks. Though this link is attributed to a …

Light has substantial influences on the physiology and behavior of most laboratory animals.
As such, lighting conditions within animal rooms are potentially significant and often …