Inside the diabetic brain: Insulin resistance and molecular mechanism associated with cognitive impairment and its possible therapeutic strategies
Type 2 diabetes mellitus (T2DM) the most prevalent metabolic disease that has evolved into
a major public health issue. Concerning about its secondary complications, a growing body …
a major public health issue. Concerning about its secondary complications, a growing body …
Brain insulin resistance: a treatment target for cognitive impairment and anhedonia in depression
Abstract Type 2 Diabetes Mellitus (T2DM) and Major Depressive Disorder (MDD) are
leading causes of disability worldwide. Indeed, both are costly and burdensome diseases at …
leading causes of disability worldwide. Indeed, both are costly and burdensome diseases at …
Insulin resistance exacerbates Alzheimer disease via multiple mechanisms
Alzheimer disease (AD) is a chronic neurodegenerative disease that accounts for 60–70%
of dementia and is the sixth leading cause of death in the United States. The pathogenesis …
of dementia and is the sixth leading cause of death in the United States. The pathogenesis …
[HTML][HTML] Migraine, brain glucose metabolism and the “neuroenergetic” hypothesis: a scoping review
Increasing evidence suggests that migraine may be the result of an impaired brain glucose
metabolism. Several studies have reported brain mitochondrial dysfunction, impaired brain …
metabolism. Several studies have reported brain mitochondrial dysfunction, impaired brain …
Sphingolipid metabolism in brain insulin resistance and neurological diseases
M Mei, M Liu, Y Mei, J Zhao, Y Li - Frontiers in Endocrinology, 2023 - frontiersin.org
Sphingolipids, as members of the large lipid family, are important components of plasma
membrane. Sphingolipids participate in biological signal transduction to regulate various …
membrane. Sphingolipids participate in biological signal transduction to regulate various …
[HTML][HTML] Association of triglyceride-glucose index with major depressive disorder: a cross-sectional study
M Jin, P Lv, H Liang, Z Teng, C Gao, X Zhang, A Ni… - Medicine, 2023 - journals.lww.com
The triglyceride-glucose (TyG) index has been proposed as a new marker for insulin
resistance, which is associated with a risk of major depressive disorder (MDD). This study …
resistance, which is associated with a risk of major depressive disorder (MDD). This study …
Depression-like behavior, hyperglycemia, oxidative stress, and neuroinflammation presented in diabetic mice are reversed by the administration of 1-methyl-3 …
SR Bampi, AM Casaril, M Domingues… - Journal of Psychiatric …, 2020 - Elsevier
Oxidative stress and neuroinflammation are found both in diabetes mellitus and major
depressive disorder (MDD). In addition to damage in peripheral organs, such as liver and …
depressive disorder (MDD). In addition to damage in peripheral organs, such as liver and …
Longitudinal association between triglyceride glucose index and depression progression in middle-aged and elder adults: a national retrospective cohort study
L Zheng, C Cui, S Yue, H Yan, T Zhang, M Ding… - Nutrition, Metabolism …, 2023 - Elsevier
Background and aims Psychological symptoms are prevalent among individuals with non-
communicable diseases, while the longitudinal association between triglyceride glucose …
communicable diseases, while the longitudinal association between triglyceride glucose …
High fat-low protein diet induces metabolic alterations and cognitive dysfunction in female rats
Approximately one-third of the world population is suffering from MetS, and the same is
expected to rise in the years to come. Worldwide, most of the staple diets contain high …
expected to rise in the years to come. Worldwide, most of the staple diets contain high …
Neurobehavioral alterations in a mouse model of chronic partial sleep deprivation
The night shift paradigm induces a state of chronic partial sleep deprivation (CPSD) and
enhances the vulnerability to neuronal dysfunction. However, the specific neuronal impact of …
enhances the vulnerability to neuronal dysfunction. However, the specific neuronal impact of …