All components of the CNS are surrounded by a diffuse extracellular matrix (ECM)
containing chondroitin sulphate proteoglycans (CSPGs), heparan sulphate proteoglycans …

Neuroplasticity refers to the ability of brain circuits to reorganize and change the properties
of the network, resulting in alterations in brain function and behavior. It is traditionally …

Glycan alterations are associated with aging, neuropsychiatric, and neurodegenerative
diseases, although the contributions of specific glycan structures to emotion and cognitive …

Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround
the soma and proximal dendrites of certain neurons in the central nervous system …

Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) structures found
throughout the central nervous system that regulate plasticity. They consist of a …

The commensal microbiota plays a fundamental role in maintaining host gut homeostasis by
controlling several metabolic, neuronal and immune functions. Conversely, changes in the …

Diffuse and structured extracellular matrix (ECM) comprise∼ 20% of the brain's volume and
play important roles in development and adult plasticity. Perineuronal nets (PNNs) …

A loss of the excitation/inhibition (E/I) balance in the neural circuit has emerged as a
common neuropathological feature in many neurodevelopmental disorders. Rett syndrome …

In recent years, convergent evidence has emerged in support of the idea of social brain
networks, specific brain regions that are interconnected and support social behaviors. One …

Child maltreatment disrupts trajectories of brain development, but the underlying pathways
are unclear. Stressful stimuli in early life interfere with maturation of local inhibitory circuitry …