New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

[HTML][HTML] Bioactive natural products from Bacteroidetes

S Brinkmann, MS Spohn, TF Schäberle - Natural product reports, 2022 - pubs.rsc.org
Covering: up to end of January 2022 Bacteria representing the phylum Bacteroidetes
produce a diverse range of natural products, including polyketides, peptides and lactams …

Explication of structural variations in the bacterial and archaeal community of anaerobic digestion sludges: an insight through metagenomics

AI Alalawy, Z Guo, FM Almutairi, HA El Rabey… - Journal of …, 2021 - Elsevier
Anaerobic digestion (AD) is a biological process, encompasses the treatment and
stabilization of complex organic matter to extract renewable biomethane fuel through …

[HTML][HTML] Improved production of class I lanthipeptides in Escherichia coli

H Lee, C Wu, EK Desormeaux, R Sarksian… - Chemical …, 2023 - pubs.rsc.org
Lanthipeptides are ribosomally synthesised and post-translationally modified peptides
containing lanthionine (Lan) and methyllanthionine (MeLan) residues that are formed by …

[HTML][HTML] The Rare Actinobacterium Crossiella sp. Is a Potential Source of New Bioactive Compounds with Activity against Bacteria and Fungi

JL Gonzalez-Pimentel, I Dominguez-Moñino, V Jurado… - Microorganisms, 2022 - mdpi.com
Antimicrobial resistance has become a global problem in recent decades. A gradual
reduction in drug discoveries has led to the current antimicrobial resistance crisis. Caves …

Structural Analysis of Class I Lanthipeptides from Pedobacter lusitanus NL19 Reveals an Unusual Ring Pattern

IR Bothwell, T Caetano, R Sarksian, S Mendo… - ACS chemical …, 2021 - ACS Publications
Lanthipeptides are ribosomally synthesized and post-translationally modified peptide
natural products characterized by the presence of lanthionine and methyllanthionine cross …

[HTML][HTML] Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes

D Xue, EA Older, Z Zhong, Z Shang, N Chen… - Nature …, 2022 - nature.com
Bacterial natural product biosynthetic genes, canonically clustered, have been increasingly
found to rely on hidden enzymes encoded elsewhere in the genome for completion of …

Deciphering the Biosynthesis of Novel Class I Lanthipeptides from Marine Pseudoalteromonas Reveals a Dehydratase PsfB with Dethiolation Activity

X Wang, Z Wang, Z Dong, Y Yan, Y Zhang… - ACS Chemical …, 2023 - ACS Publications
Lanthipeptides are a representative class of RiPPs that possess characteristic lanthionine
and/or methyllanthionine thioether cross-links. The biosynthetic potentials of marine-derived …

[HTML][HTML] Bioinformatic mining for RiPP biosynthetic gene clusters in Bacteroidales reveals possible new subfamily architectures and novel natural products

MV Fernandez-Cantos, D Garcia-Morena, Y Yi… - Frontiers in …, 2023 - frontiersin.org
The Bacteroidales order, widely distributed among diverse human populations, constitutes a
key component of the human microbiota. Members of this Gram-negative order have been …

The Unexplored Wealth of Microbial Secondary Metabolites: the Sphingobacteriaceae Case Study

G Figueiredo, M Gomes, C Covas, S Mendo… - Microbial ecology, 2022 - Springer
Research on secondary metabolites (SMs) has been mostly focused on Gram-positive
bacteria, especially Actinobacteria. The association of genomics with robust bioinformatics …