Tumor budding is an important additional prognostic factor for patients with colorectal cancer
(CRC). Defined as the presence of single tumor cells or small clusters of up to 5 cells in the …

With the prevalence of endoscopic submucosal dissection and endoscopic full thickness
resection, which enable complete resection of T1 colorectal cancer with a negative margin …

Background & Aims Deep submucosal invasion (DSI) is considered a key risk factor for
lymph node metastasis (LNM) and important criterion to recommend surgery in T1 colorectal …

Although tumour budding is an adverse prognostic factor for many cancer types, the
molecular mechanisms governing this phenomenon are incompletely understood …

Worldwide, colorectal cancer (CRC) screening programs have significantly increased the
detection of submucosal (pT1) adenocarcinoma. Completion surgery may be indicated after …

Context.—Tumor budding has received increasing recognition as an important independent
prognostic factor in colorectal carcinoma. Prominent tumor budding in adenocarcinoma …

Pathologic assessment of colorectal cancer specimens plays an essential role in patient
management, informing prognosis and contributing to therapeutic decision making. The …

Evidence has now accumulated that colonoscopy and removal of polyps, especially during
screening and surveillance programs, is effective in overall risk reduction for colon cancer …

Collagen triple helix repeat containing (CTHRC1), which was identified as a cancer‐related
factor, is a promigratory protein involved in multiple processes, including vascular …

BACKGROUND: Treatment of endoscopically resected T1 colorectal cancers is based on
the risk of lymph node metastasis. Risk is based on histopathologic features, although there …