Psychotropic medication efficacy and tolerability are critical treatment issues faced by
individuals with psychiatric disorders and their healthcare providers. For some people, it can …

In the past two decades, significant progress has been made in the development of
polygenic scores (PGSs). One specific application of PGSs is the development and potential …

Cytochrome P450 enzymes including CYP2C19 and CYP2D6 are important for
antidepressant metabolism and polymorphisms of these genes have been determined to …

Importance Predictors consistently associated with psychosis liability and course of illness in
schizophrenia (SCZ) spectrum disorders (SSD), including the need for clozapine treatment …

Treatment-resistant symptoms occur in about a third of patients with schizophrenia and are
associated with a substantial reduction in their quality of life. The development of new …

Although treatment-resistant schizophrenia (TRS) is an important and frequent problem with
a specific treatment, clozapine, its biological determinants are poorly understood. At the …

Clozapine is often underused due to concerns about adverse drug reactions (ADRs) but
studies into their prevalences are inconclusive. We therefore comprehensively examined …

Treatment-resistant schizophrenia (TRS) is often associated with severe burden of disease,
poor quality of life and functional impairment. Clozapine is the gold standard for the …

Background Electroconvulsive therapy (ECT) is the most effective treatment for severe major
depressive episodes (MDEs). Nonetheless, firmly established associations between ECT …

Background Unpacking molecular perturbations associated with features of schizophrenia is
a critical step toward understanding phenotypic heterogeneity in this disorder. Recent …