Hepatic encephalopathy (HE) is a neurological complication of liver disease resulting in
cognitive, psychiatric, and motor symptoms. Although hyperammonemia is a key factor in the …

Hyperammonemia is necessary for development of the cerebral complications to liver
disease including hepatic encephalopathy and cerebral edema but the mechanisms are …

Pre-diabetes, a risk factor for type 2 diabetes development, leads to metabolic changes at
testicular level. Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) and …

A major roadblock to the application of bioartificial livers is the need for a human liver cell
line that displays a high and broad level of hepatic functionality. The human bipotent liver …

A novel gold nanoparticles–single-walled carbon nanohorn (GNPs–SWCNH) hybrid was
synthesized for the construction of an amperometric biosensing platform. The GNPs …

Introduction: Bioartificial livers (BALs) are urgently needed to bridge severe liver failure
patients to liver transplantation or liver regeneration. When based on primary hepatocytes …

Rheumatoid arthritis (RA), a chronic systemic autoimmune disease, is mainly characterized
by joint lesions and permanent loss of joint function. To discover the metabolic …

Hepatic Encephalopathy (HE) is associated with abnormalities in brain metabolism of
glucose, oxygen and amino acids. In patients with acute liver failure, cortical lactate to …

Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome, is a frequent
complication of liver failure/disease. Increased concentrations of lactate are commonly …

A better knowledge of the pathogenesis of brain disturbances in acute-on-chronic liver
failure provides the rationale for using ammonia-focused therapy in the prevention and …