The concept of a scaffold concerns many aspects at different steps on the drug development
path. In medicinal chemistry, the choice of relevant “drug-likeness” scaffold is a starting point …

Combretastatins are a class of closely related stilbenes (combretastatins A),
dihydrostilbenes (combretastatins B), phenanthrenes (combretastatins C) and macrocyclic …

The antitumor efficacy of Chinese herbal medicines has been widely recognized. Leading
compounds such as sterols, glycosides, flavonoids, alkaloids, terpenoids …

An approach in modern medicinal chemistry to discover novel bioactive compounds is by
mimicking diverse complementary pharmacophores. In extension of this strategy, a new …

Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as
well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the …

A library of new phenstatin based indole linked chalcone compounds (9a-z and 9aa-ad)
were designed and synthesized. Of these, compound 9a with 1-methyl, 2-and 3-methoxy …

Isoxazole derivatives are one of the heterocyclic structures that have various biological
activities. Objective: This study aimed to design and synthesize novel isoxazole derivatives …

Three new derivatives of tetrahydrocurcumin 6, 7 and 9 have been prepared as potent
antitumor agents using copper (II)-catalyzed 'click chemistry'. Their structures were identified …

A new series of N-(2-(1H-benzo [d] imidazol-2-yl) phenyl) cinnamides was prepared and
evaluated for their in vitro cytotoxic activity using various cancer cell lines viz. A549 (human …

A transition metal-catalyzed carbene insertion strategy has been developed to activate the
inactivated sp2 C–H bond of medicinally important cis-stilbene acids. This approach …