Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

Gene expression in Kinetoplastids is very unusual in that the open reading frames are
arranged in long polycistronic arrays, monocistronic mRNAs being created by post …

Leishmania has a plastic genome, and drug pressure can select for gene copy number
variation (CNV). CNVs can apply either to whole chromosomes, leading to aneuploidy, or to …

Leishmania are protozoan parasites that cause a wide spectrum of clinical diseases in
humans and are a major public health risk in several countries. Leishmania life cycle …

Kinetoplastids branched early from the eukaryotic lineage and include several parasitic
protozoan species. Up to several hundred kinetoplastid genes are co-transcribed into …

Abstract The Leishmania tarentolae Parrot-TarII strain genome sequence was resolved to an
average 16-fold mean coverage by next-generation DNA sequencing technologies. This is …

Kinetoplastids, including the human pathogens Trypanosoma brucei, Trypanosoma cruzi
and Leishmania, are the only known organisms that do not regulate the transcription of …

Antimonials remain the first line drug against the protozoan parasite Leishmania but their
efficacy is threatened by resistance. We carried out a RNA expression profiling analysis …

Leishmania spp. are protozoan parasites that have two principal life cycle stages: the motile
promastigote forms that live in the alimentary tract of the sandfly and the amastigote forms …

Protozoan parasites of the genus Leishmania are found as promastigotes in the sandfly
vector and as amastigotes in mammalian macrophages. Mechanisms controlling stage …