Complexities of the glomerular basement membrane

RW Naylor, MRPT Morais, R Lennon - Nature Reviews Nephrology, 2021 - nature.com
The glomerular basement membrane (GBM) is a key component of the glomerular capillary
wall and is essential for kidney filtration. The major components of the GBM include …

Membranous nephropathy: new pathogenic mechanisms and their clinical implications

E Hoxha, L Reinhard, RAK Stahl - Nature Reviews Nephrology, 2022 - nature.com
Membranous nephropathy (MN) is characterized histomorphologically by the presence of
immune deposits in the subepithelial space of the glomerular filtration barrier; its clinical …

Membranous nephropathy: mechanistic insights and therapeutic perspectives

MR Hua, YL Zhao, JZ Yang, L Zou, YY Zhao… - International …, 2023 - Elsevier
Membranous nephropathy (MN) is one of the most common causes of non-diabetic
nephrotic syndrome in adults. About 80% of cases are renal limited (primary MN) and 20 …

[HTML][HTML] Single-cell profiling reveals transcriptional signatures and cell-cell crosstalk in anti-PLA2R positive idiopathic membranous nephropathy patients

J Xu, C Shen, W Lin, T Meng, JD Ooi… - Frontiers in …, 2021 - frontiersin.org
Idiopathic membranous nephropathy (IMN) is an organ-specific autoimmune disease of the
kidney glomerulus. It may gradually progress to end-stage renal disease (ESRD) …

[HTML][HTML] Th17-Immune response in patients with membranous nephropathy is associated with thrombosis and relapses

M Cremoni, V Brglez, S Perez, F Decoupigny… - Frontiers in …, 2020 - frontiersin.org
Membranous nephropathy (MN) is a rare autoimmune kidney disease. Most autoimmune
diseases are associated with a pro-inflammatory Th17-immune response, but little is known …

[HTML][HTML] Contactin-1 links autoimmune neuropathy and membranous glomerulonephritis

J Fehmi, AJ Davies, M Antonelou, S Keddie… - PloS one, 2023 - journals.plos.org
Membranous glomerulonephritis (MGN) is a common cause of nephrotic syndrome in adults,
mediated by glomerular antibody deposition to an increasing number of newly recognised …

[HTML][HTML] Helper T cells in idiopathic membranous nephropathy

Q Zhao, H Dai, X Liu, H Jiang, W Liu, Z Feng… - Frontiers in …, 2021 - frontiersin.org
Idiopathic membranous nephropathy (IMN) is an autoimmune disease in which the immune
system produces an antibody response to its own antigens due to impaired immune …

[HTML][HTML] Idiopathic membranous nephropathy: glomerular pathological pattern caused by extrarenal immunity activity

W Liu, C Gao, Z Liu, H Dai, Z Feng, Z Dong… - Frontiers in …, 2020 - frontiersin.org
Idiopathic membranous nephropathy (IMN) is a pathological pattern of glomerular damage
caused by an autoimmune response. Immune complex deposition, thickness of glomerular …

Glomerular endothelial cell-derived microRNA-192 regulates nephronectin expression in idiopathic membranous glomerulonephritis

J Müller-Deile, N Sopel, A Ohs, V Rose… - Journal of the …, 2021 - journals.lww.com
Background Autoantibodies binding to podocyte antigens cause idiopathic membranous
glomerulonephritis (iMGN). However, it remains elusive how autoantibodies reach the …

A novel insight into the role of PLA2R and THSD7A in membranous nephropathy

P Zhang, W Huang, Q Zheng, J Tang… - Journal of …, 2021 - Wiley Online Library
Membranous nephropathy (MN) is an organ‐restricted autoimmune disease mainly caused
by circulating autoantibodies against podocyte antigens, including the M‐type …