Antibodies to combat viral infections: development strategies and progress

G Pantaleo, B Correia, C Fenwick, VS Joo… - Nature Reviews Drug …, 2022 - nature.com
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …

Developing therapeutic approaches for twenty-first-century emerging infectious viral diseases

RM Meganck, RS Baric - Nature medicine, 2021 - nature.com
The twenty-first century has already recorded more than ten major epidemic or pandemic
virus emergence events, including the ongoing and devastating coronavirus disease 2019 …

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

A Wahl, LE Gralinski, CE Johnson, W Yao, M Kovarova… - Nature, 2021 - nature.com
All coronaviruses known to have recently emerged as human pathogens probably
originated in bats. Here we use a single experimental platform based on immunodeficient …

Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

NB Mercado, R Zahn, F Wegmann, C Loos… - Nature, 2020 - nature.com
A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic …

[HTML][HTML] SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract

YJ Hou, K Okuda, CE Edwards, DR Martinez… - Cell, 2020 - cell.com
The mode of acquisition and causes for the variable clinical spectrum of coronavirus disease
2019 (COVID-19) remain unknown. We utilized a reverse genetics system to generate a …

DNA vaccine protection against SARS-CoV-2 in rhesus macaques

J Yu, LH Tostanoski, L Peter, NB Mercado, K McMahan… - Science, 2020 - science.org
The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has made the development of a vaccine …

The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

L Premkumar, B Segovia-Chumbez, R Jadi… - Science …, 2020 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first emerged in
late 2019 is responsible for a pandemic of severe respiratory illness. People infected with …

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

KH Dinnon III, SR Leist, A Schäfer, CE Edwards… - Nature, 2020 - nature.com
Coronaviruses are prone to transmission to new host species, as recently demonstrated by
the spread to humans of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

[HTML][HTML] Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses

KO Saunders, E Lee, R Parks, DR Martinez, D Li… - Nature, 2021 - nature.com
Betacoronaviruses caused the outbreaks of severe acute respiratory syndrome (SARS) and
Middle East respiratory syndrome, as well as the current pandemic of SARS coronavirus 2 …

An infectious cDNA clone of SARS-CoV-2

X Xie, A Muruato, KG Lokugamage, K Narayanan… - Cell host & …, 2020 - cell.com
The ongoing pandemic of COVID-19, caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), underscores the urgency to develop experimental systems for …