Rational approaches, design strategies, structure activity relationship and mechanistic insights for therapeutic coumarin hybrids
Hybrid molecules, furnished by combining two or more pharmacophores is an emerging
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …
Factor XII as a therapeutic target in thromboembolic and inflammatory diseases
KF Nickel, AT Long, TA Fuchs, LM Butler… - … , and vascular biology, 2017 - Am Heart Assoc
Coagulation factor XII (FXII, Hageman factor) is a plasma protease that in its active form
(FXIIa) initiates the procoagulant and proinflammatory contact system. This name arises from …
(FXIIa) initiates the procoagulant and proinflammatory contact system. This name arises from …
[HTML][HTML] Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
J Wilbs, XD Kong, SJ Middendorp, R Prince… - Nature …, 2020 - nature.com
Inhibiting thrombosis without generating bleeding risks is a major challenge in medicine. A
promising solution may be the inhibition of coagulation factor XII (FXII), because its knock …
promising solution may be the inhibition of coagulation factor XII (FXII), because its knock …
Monocarbonyl curcumin-based molecular hybrids as potent antibacterial agents
Keeping in view various pharmacological attributes of curcumin, coumarin, and isatin
derivatives, triazole-tethered monocarbonyl curcumin–coumarin and curcumin–isatin …
derivatives, triazole-tethered monocarbonyl curcumin–coumarin and curcumin–isatin …
Design, synthesis, antimicrobial evaluation, and molecular modeling studies of novel indolinedione–coumarin molecular hybrids
Keeping in view various pharmacological attributes of indole and coumarin derivatives, a
new series of indolindione–coumarin molecular hybrids was rationally designed and …
new series of indolindione–coumarin molecular hybrids was rationally designed and …
The antithrombotic activity of natural and synthetic coumarins
Thrombosis, which seriously endangers human health and life, is the leading cause of
morbidity and mortality globally. Antithrombotic drugs can interfere with the occurrence and …
morbidity and mortality globally. Antithrombotic drugs can interfere with the occurrence and …
[HTML][HTML] Synthetic coumarin derivatives with anticoagulation and antiplatelet aggregation inhibitory effects
Thrombosis is the leading cause of illness and mortality worldwide, posing a serious risk to
human health and life. Because antithrombotic drugs can prevent the beginning and …
human health and life. Because antithrombotic drugs can prevent the beginning and …
Factor XII/XIIa inhibitors: Their discovery, development, and potential indications
Coagulation factor XII (FXII), a S1A serine protease, was discovered more than fifty years
ago. However, its in vivo functions and its three-dimensional structure started to be disclosed …
ago. However, its in vivo functions and its three-dimensional structure started to be disclosed …
Factor XII (a) inhibitors: a review of the patent literature
DV Kalinin - Expert Opinion on Therapeutic Patents, 2021 - Taylor & Francis
Introduction: Blood coagulation factor XII (FXII) is an emerging and potentially safe drug
target, which dysregulation is associated with thrombosis, hereditary angioedema, and …
target, which dysregulation is associated with thrombosis, hereditary angioedema, and …
The choice of targets and ligands for site-specific delivery of nanomedicine to atherosclerosis
As nanotechnologies advance into clinical medicine, novel methods for applying
nanomedicine to cardiovascular diseases are emerging. Extensive research has been …
nanomedicine to cardiovascular diseases are emerging. Extensive research has been …