As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

Microvascular and metabolic physiology are tightly linked. This Perspective reviews
evidence that 1) the relationship between hyperglycemia and microvascular dysfunction …

Skeletal muscle conveys several of the health-promoting effects of exercise; yet the
underlying mechanisms are not fully elucidated. Studying skeletal muscle is challenging due …

Insulin is a major endocrine hormone also involved in the regulation of energy and lipid
metabolism via the activation of an intracellular signaling cascade involving the insulin …

Impaired insulin signaling is central to development of the metabolic syndrome and can
promote cardiovascular disease indirectly through development of abnormal glucose and …

Adiponectin is secreted by adipose cells and mimics many metabolic actions of insulin.
However, mechanisms by which adiponectin acts are poorly understood. The vascular …

Strength training represents an alternative to endurance training for patients with type 2
diabetes. Little is known about the effect on insulin action and key proteins in skeletal …

Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …

Four grams of glucose circulates in the blood of a person weighing 70 kg. This glucose is
critical for normal function in many cell types. In accordance with the importance of these 4 g …

ContextEndothelial dysfunction occurs in diagnosed type 2 diabetes mellitus but may also
precede development of diabetes. ObjectiveTo determine whether elevated plasma levels of …