Long-term normothermic machine preservation of human livers: what is needed to succeed?

B Lascaris, AM Thorne, T Lisman… - American Journal …, 2022 - journals.physiology.org
Although short‐term machine perfusion (≤ 24 h) allows for resuscitation and viability
assessment of high‐risk donor livers, the donor organ shortage might be further remedied by …

[HTML][HTML] Assessing donor liver quality and restoring graft function in the era of extended criteria donors

Y Lin, H Huang, L Chen, R Chen, J Liu… - Journal of Clinical …, 2023 - ncbi.nlm.nih.gov
Liver transplantation (LT) is the final treatment option for patients with end-stage liver
disease. The increasing donor shortage results in the wide usage of grafts from extended …

Challenging the ex vivo lung perfusion procedure with continuous dialysis in a pig model

J De Wolf, M Glorion, L Jouneau, J Estephan… - …, 2022 - journals.lww.com
Background. Normothermic ex vivo lung perfusion (EVLP) increases the pool of donor lungs
by requalifying marginal lungs refused for transplantation through the recovery of …

Development of a rat liver machine perfusion system for normothermic and subnormothermic conditions

M Nösser, JMGV Gassner, S Moosburner… - … engineering Part A, 2020 - liebertpub.com
Ex vivo liver machine perfusion (MP) is a promising alternative for preservation of liver grafts
from extended criteria donors. Small animal models can be used to evaluate different …

Engineering an endothelialized, endocrine Neo-Pancreas: Evaluation of islet functionality in an ex vivo model

H Everwien, E Keshi, KH Hillebrandt, B Ludwig… - Acta Biomaterialia, 2020 - Elsevier
Islet-based recellularization of decellularized, repurposed rat livers may form a
transplantable Neo-Pancreas. The aim of this study is the establishment of the necessary …

Incorporating a hemodialysis filter into a commercial normothermic perfusion system to facilitate long‐term preservation of human split‐livers

J Huang, NS Lau, M Ly, D Babekuhl, P Yousif… - Artificial …, 2024 - Wiley Online Library
Background Normothermic machine perfusion (NMP) allows for the assessment and
resuscitation of ex‐vivo human livers prior to transplantation. Commercially available NMP …

Hemofiltration improves blood perfusate conditions leading to improved ex situ heart perfusion

SEK genaamd Dengler, M Mishra, MT Vervoorn… - ASAIO …, 2024 - journals.lww.com
The aim was to optimize the perfusate composition by including a hemofiltrator to the
PhysioHeartplatform for ex situ heart perfusion of porcine slaughterhouse hearts. Fourteen …

Optimizing environmental enrichment for Sprague Dawley rats: Exemplary insights into the liver proteome

NN Roschke, KH Hillebrandt, D Polenz, O Klein… - Plos one, 2024 - journals.plos.org
Background Considering the expected increase in the elderly population and the growing
emphasis on aging-related biomedical research, the demand for aged laboratory animals …

Normothermic Ex Vivo Liver Machine Perfusion in Mouse

H Chen, O Dirsch, M Albadry, PH Ana… - JoVE (Journal of …, 2023 - jove.com
This protocol presents an optimized erythrocytes-free NEVLP system using mouse livers. Ex
vivo preservation of mouse livers was achieved by employing modified cannulas and …

Quality assessment by bile composition in normothermic machine perfusion of rat livers

V Muth, F Stobl, J Michelotto, L Gilles… - … Engineering Part A, 2024 - liebertpub.com
Background: The persistent challenge of organ scarcity in liver transplantation leads to an
escalating dependence on organs obtained from extended criteria donors (ECD) …