Folates have a pterine core structure and high metabolic activity due to their ability to accept
electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential …

Today, in diverse medical and clinical fields, including cancer treatment, nanoscience has
evolved and evolved. Cancer and its forms, on the other hand, have been rumored and …

Folate receptors (FRα, FRβ and FRγ) are cysteine-rich cell-surface glycoproteins that bind
folate with high affinity to mediate cellular uptake of folate. Although expressed at very low …

In the past 65 years, antifolates targeting folate metabolism played a pivotal role in drug
treatment of malignant, microbial, parasitic and chronic inflammatory diseases. Drug …

Until recently, the transport of folates into cells and across epithelia has been interpreted
primarily within the context of two transporters with high affinity and specificity for folates, the …

Members of the family of B9 vitamins are commonly known as folates. They are derived
entirely from dietary sources and are key one-carbon donors required for de novo nucleotide …

Membrane transport of folates Page 424 12 Membrane Transport of Folates Larry H.
Matherly The Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos …

Hyperhomocysteinaemia has been regarded as a new modifiable risk factor for
atherosclerosis and vascular disease. Homocysteine is a branch‐point intermediate of …

This review attempts to provide a comprehensive overview of the biology of the
physiologically and pharmacologically important transport system termed the “reduced folate …

Antifolates are structural analogs of folates, essential one-carbon donors in the synthesis of
DNA in mammalian cells. Antifolates are inhibitors of key enzymes in folate metabolism …