Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …

Understanding of human brain development, dysfunction and neurological diseases has
remained limited and challenging due to inability to recapitulate human brain-specific …

Human spinal-cord-like tissues induced from human pluripotent stem cells are typically
insufficiently mature and do not mimic the morphological features of neurulation. Here, we …

Investigation of neural circuit dynamics is crucial for deciphering the functional connections
among regions of the brain and understanding the mechanism of brain dysfunction. Despite …

Realizing the full potential of organoids and assembloids to model neural development and
disease will require improved methods for long-term, minimally invasive recording of …

The bioengineerined and whole matured human brain organoids stand as highly valuable
three-dimensional in vitro brain-mimetic models to recapitulate in vivo brain development …

Although historically, the traditional bidimensional in vitro cell system has been widely used
in research, providing much fundamental information regarding cellular functions and …

Over a decade of schizophrenia research using human induced pluripotent stem cell (iPSC)-
derived neural models has provided substantial data describing neurobiological …

While some individuals age without pathological memory impairments, others develop age‐
associated cognitive diseases. Since changes in cognitive function develop slowly over time …

Research on critical periods of brain development is greatly expanding our understanding of
the cellular and molecular mechanisms underlying the epochs of heightened plasticity …