Primary gene induction or repression in eukaryotes does not require de novo protein
synthesis, suggesting the involvement of posttranslational modifications. Since many …

The cyclin-dependent protein kinase (CDK) encoded by CDC28 is the master regulator of
cell division in the budding yeast Saccharomyces cerevisiae. By mechanisms that, for the …

The interactions between proteins, DNA, and RNA in living cells constitute molecular
networks that govern various cellular functions. To investigate the global dynamical …

Point mutagenesis of the nuclear targeting sequence of nucleoplasmin has identified two
interdependent basic domains. These are separated by 10 intervening" spacer" amino acids …

Msn2p and the partially redundant factor Msn4p are key regulators of stress-responsive
gene expression in Saccharomyces cerevisiae. They are required for the transcription of a …

Exit from mitosis requires the inactivation of mitotic cyclin-dependent kinases (CDKs) by an
unknown mechanism. We show that the Cdc14 phosphatase triggers mitotic exit by three …

Genome-wide location analysis was used to determine how the yeast cell cycle gene
expression program is regulated by each of the nine known cell cycle transcriptional …

How sister cells can have different fates is a fundamental aspect of the problem of how cell
diversity is generated during development. In principle, sister cells that aredifferent could be …

▪ Abstract Completion of the cell cycle requires the temporal and spatial coordination of
chromosome segregation with mitotic spindle disassembly and cytokinesis. In budding …

The molecular machinery of cell cycle control is known in more detail for budding yeast,
Saccharomyces cerevisiae, than for any other eukaryotic organism. In recent years, many …