Recent results from laboratory investigations and clinical trials indicate important roles for
estrogen receptor (ER) agonists in protecting the central nervous system (CNS) from …

Dissecting the molecular pathways employed by estrogen to modulate CD4+ T cells will be
critical in elucidating the manner by which estrogen exerts its effects on this compartment …

The mechanisms by which prolonged estrogen exposures, such as estrogen therapy and
pregnancy, reduce thymus weight, cellularity, and CD4 and CD8 phenotype expression …

Although it has been established that high levels of estrogen can induce thymic involution,
the mechanism by which this happens is not known. We have found that daily ip injections of …

Bioflavanoids are the major pigments in plants with multitude of biological activities
including inhibition of proliferation or induction of apoptosis in tumor cells. Eventhough the …

Estrogenic endocrine disrupting compounds (EEDCs) can cause alterations in sexual
development and reproductive function of fish. Growing evidence suggests that EEDCs can …

Bone mass is determined by bone cell differentiation, activity, and death, which mainly occur
through apoptosis. Apoptosis can be triggered by death receptor Fas (CD95), expressed on …

The present review summarizes recent data on age-related thymic changes termed thymic
involution, and highlights the putative role of perturbances in extrathymical and, possibly …

Defective control of T cell apoptosis is considered to be one of the pathogenetic
mechanisms in systemic lupus erythematosus (SLE). Oestrogen has been known to …

The ability of the thymus gland to convert bone marrow-derived progenitor cells into single
positive (SP) T-cells is well known. In this review we present evidence that the thymus, in …