Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly
expressed in the liver and intestine. Upon ligand binding, FXR regulates key genes involved …

Farnesoid X receptor (FXR), a metabolic nuclear receptor, plays critical roles in the
maintenance of systemic energy homeostasis and the integrity of many organs, including …

Farnesoid X receptor (FXR) is an important regulator of bile acid, lipid, amino acid, and
glucose homeostasis, hepatic inflammation, regeneration, and fibrosis. FXR has been …

Alzheimer's disease (AD) is a progressively neurodegenerative disease characterized by
cognitive deficits and alteration of personality and behavior. As yet, there is no efficient …

Farnesoid X receptor (FXR) influences bile acid homeostasis and the progression of various
diseases. While the roles of hepatic and intestinal FXR in enterohepatic transport of bile …

Nuclear receptors (NRs) constitute a superfamily of ligand-activated transcription factors with
a paramount role in ubiquitous physiological functions such as metabolism, growth, and …

ABSTRACT Introduction The Farnesoid X receptor (FXR) is a key transcription factor that is
involved in the bile acid signaling network. The modulation of the FXR activity influences …

Nuclear receptors (NRs) form a family of druggable transcription factors that are regulated by
ligand binding to orchestrate multifaceted physiological functions, including reproduction …

During the last decades, it has become clear that the gastrointestinal tract plays a pivotal
role in the regulation of glucose homeostasis. More than 40 hormones originate from the …

Cardiometabolic diseases are characterized as a combination of multiple risk factors for
cardiovascular disease (CVD) and metabolic diseases including diabetes mellitus and …