[HTML][HTML] Farnesoid X receptor (FXR): Structures and ligands
L Jiang, H Zhang, D Xiao, H Wei, Y Chen - Computational and structural …, 2021 - Elsevier
Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly
expressed in the liver and intestine. Upon ligand binding, FXR regulates key genes involved …
expressed in the liver and intestine. Upon ligand binding, FXR regulates key genes involved …
Update on FXR biology: promising therapeutic target?
CY Han - International journal of molecular sciences, 2018 - mdpi.com
Farnesoid X receptor (FXR), a metabolic nuclear receptor, plays critical roles in the
maintenance of systemic energy homeostasis and the integrity of many organs, including …
maintenance of systemic energy homeostasis and the integrity of many organs, including …
Recent advances in the medicinal chemistry of farnesoid X receptor
Farnesoid X receptor (FXR) is an important regulator of bile acid, lipid, amino acid, and
glucose homeostasis, hepatic inflammation, regeneration, and fibrosis. FXR has been …
glucose homeostasis, hepatic inflammation, regeneration, and fibrosis. FXR has been …
Antiallergic drug desloratadine as a selective antagonist of 5HT2A receptor ameliorates pathology of Alzheimer's disease model mice by improving microglial …
Alzheimer's disease (AD) is a progressively neurodegenerative disease characterized by
cognitive deficits and alteration of personality and behavior. As yet, there is no efficient …
cognitive deficits and alteration of personality and behavior. As yet, there is no efficient …
The pathophysiological function of non-gastrointestinal farnesoid X receptor
Farnesoid X receptor (FXR) influences bile acid homeostasis and the progression of various
diseases. While the roles of hepatic and intestinal FXR in enterohepatic transport of bile …
diseases. While the roles of hepatic and intestinal FXR in enterohepatic transport of bile …
Harnessing oleanolic acid and its derivatives as modulators of metabolic nuclear receptors
Nuclear receptors (NRs) constitute a superfamily of ligand-activated transcription factors with
a paramount role in ubiquitous physiological functions such as metabolism, growth, and …
a paramount role in ubiquitous physiological functions such as metabolism, growth, and …
Patented Farnesoid X receptor modulators: a review (2019–present)
A Gioiello, E Rosatelli, B Cerra - Expert Opinion on Therapeutic …, 2024 - Taylor & Francis
ABSTRACT Introduction The Farnesoid X receptor (FXR) is a key transcription factor that is
involved in the bile acid signaling network. The modulation of the FXR activity influences …
involved in the bile acid signaling network. The modulation of the FXR activity influences …
Overview of ursolic acid potential for the treatment of metabolic disorders, autoimmune diseases, and cancers via nuclear receptor pathways
SF Kadasah, MO Radwan - Biomedicines, 2023 - mdpi.com
Nuclear receptors (NRs) form a family of druggable transcription factors that are regulated by
ligand binding to orchestrate multifaceted physiological functions, including reproduction …
ligand binding to orchestrate multifaceted physiological functions, including reproduction …
Mechanisms in endocrinology: FXR signalling: a novel target in metabolic diseases
DP Sonne - European Journal of Endocrinology, 2021 - academic.oup.com
During the last decades, it has become clear that the gastrointestinal tract plays a pivotal
role in the regulation of glucose homeostasis. More than 40 hormones originate from the …
role in the regulation of glucose homeostasis. More than 40 hormones originate from the …
Farnesoid X receptor agonists as therapeutic target for cardiometabolic diseases
C Li, J Yang, Y Wang, Y Qi, W Yang, Y Li - Frontiers in pharmacology, 2020 - frontiersin.org
Cardiometabolic diseases are characterized as a combination of multiple risk factors for
cardiovascular disease (CVD) and metabolic diseases including diabetes mellitus and …
cardiovascular disease (CVD) and metabolic diseases including diabetes mellitus and …