Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease
Trimethylamine N-oxide (TMAO) is a biologically active molecule and is a putative promoter
of chronic diseases including atherosclerosis in humans. Host intestinal bacteria produce its …
of chronic diseases including atherosclerosis in humans. Host intestinal bacteria produce its …
Use of metabolomics in improving assessment of dietary intake
M Guasch-Ferré, SN Bhupathiraju, FB Hu - Clinical chemistry, 2018 - academic.oup.com
BACKGROUND Nutritional metabolomics is rapidly evolving to integrate nutrition with
complex metabolomics data to discover new biomarkers of nutritional exposure and status …
complex metabolomics data to discover new biomarkers of nutritional exposure and status …
Plasma levels of trimethylamine-N-oxide can be increased with 'healthy'and 'unhealthy'diets and do not correlate with the extent of atherosclerosis but with plaque …
Aims The microbiome-derived metabolite trimethylamine-N-oxide (TMAO) has attracted
major interest and controversy both as a diagnostic biomarker and therapeutic target in …
major interest and controversy both as a diagnostic biomarker and therapeutic target in …
Diets high in resistant starch increase plasma levels of trimethylamine-N-oxide, a gut microbiome metabolite associated with CVD risk
N Bergeron, PT Williams, R Lamendella… - British Journal of …, 2016 - cambridge.org
Production of trimethylamine-N-oxide (TMAO), a biomarker of CVD risk, is dependent on
intestinal microbiota, but little is known of dietary conditions promoting changes in gut …
intestinal microbiota, but little is known of dietary conditions promoting changes in gut …
Trimethylamine N-oxide: heart of the microbiota–CVD nexus?
We critically review potential involvement of trimethylamine N-oxide (TMAO) as a link
between diet, the gut microbiota and CVD. Generated primarily from dietary choline and …
between diet, the gut microbiota and CVD. Generated primarily from dietary choline and …
Gut microbiome in Schizophrenia: altered functional pathways related to immune modulation and atherosclerotic risk
TT Nguyen, T Kosciolek, RE Daly… - Brain, behavior, and …, 2021 - Elsevier
Emerging evidence has linked the gut microbiome changes to schizophrenia. However,
there has been limited research into the functional pathways by which the gut microbiota …
there has been limited research into the functional pathways by which the gut microbiota …
[HTML][HTML] Metabolomic profiles as reliable biomarkers of dietary composition
T Esko, JN Hirschhorn, HA Feldman, YHH Hsu… - The American journal of …, 2017 - Elsevier
Background: Clinical nutrition research often lacks robust markers of compliance,
complicating the interpretation of clinical trials and observational studies of free-living …
complicating the interpretation of clinical trials and observational studies of free-living …
[HTML][HTML] Modulation of the gut microbiota by resistant starch as a treatment of chronic kidney diseases: evidence of efficacy and mechanistic insights
Chronic kidney disease (CKD) has been associated with changes in gut microbial ecology,
or “dysbiosis,” which may contribute to disease progression. Recent studies have focused …
or “dysbiosis,” which may contribute to disease progression. Recent studies have focused …
[HTML][HTML] Metabolomics and transcriptomics pathway approach reveals outcome-specific perturbations in COPD
CI Cruickshank-Quinn, S Jacobson, G Hughes… - Scientific reports, 2018 - nature.com
Chronic obstructive pulmonary disease (COPD) comprises multiple phenotypes such as
airflow obstruction, emphysema, and frequent episodes of acute worsening of respiratory …
airflow obstruction, emphysema, and frequent episodes of acute worsening of respiratory …
The Influence of Animal- or Plant-Based Diets on Blood and Urine Trimethylamine-N-Oxide (TMAO) Levels in Humans
M Lombardo, G Aulisa, D Marcon, G Rizzo - Current Nutrition Reports, 2022 - Springer
Abstract Purpose of Review The aim of the review was to evaluate which diets are
associated with higher TMAO levels. Recent Findings Several studies have shown that …
associated with higher TMAO levels. Recent Findings Several studies have shown that …