Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease

SH Zeisel, M Warrier - Annual review of nutrition, 2017 - annualreviews.org
Trimethylamine N-oxide (TMAO) is a biologically active molecule and is a putative promoter
of chronic diseases including atherosclerosis in humans. Host intestinal bacteria produce its …

Use of metabolomics in improving assessment of dietary intake

M Guasch-Ferré, SN Bhupathiraju, FB Hu - Clinical chemistry, 2018 - academic.oup.com
BACKGROUND Nutritional metabolomics is rapidly evolving to integrate nutrition with
complex metabolomics data to discover new biomarkers of nutritional exposure and status …

Plasma levels of trimethylamine-N-oxide can be increased with 'healthy'and 'unhealthy'diets and do not correlate with the extent of atherosclerosis but with plaque …

YC Koay, YC Chen, JA Wali, AWS Luk… - Cardiovascular …, 2021 - academic.oup.com
Aims The microbiome-derived metabolite trimethylamine-N-oxide (TMAO) has attracted
major interest and controversy both as a diagnostic biomarker and therapeutic target in …

Diets high in resistant starch increase plasma levels of trimethylamine-N-oxide, a gut microbiome metabolite associated with CVD risk

N Bergeron, PT Williams, R Lamendella… - British Journal of …, 2016 - cambridge.org
Production of trimethylamine-N-oxide (TMAO), a biomarker of CVD risk, is dependent on
intestinal microbiota, but little is known of dietary conditions promoting changes in gut …

Trimethylamine N-oxide: heart of the microbiota–CVD nexus?

S Naghipour, AJ Cox, JN Peart, EF Du Toit… - Nutrition research …, 2021 - cambridge.org
We critically review potential involvement of trimethylamine N-oxide (TMAO) as a link
between diet, the gut microbiota and CVD. Generated primarily from dietary choline and …

Gut microbiome in Schizophrenia: altered functional pathways related to immune modulation and atherosclerotic risk

TT Nguyen, T Kosciolek, RE Daly… - Brain, behavior, and …, 2021 - Elsevier
Emerging evidence has linked the gut microbiome changes to schizophrenia. However,
there has been limited research into the functional pathways by which the gut microbiota …

[HTML][HTML] Metabolomic profiles as reliable biomarkers of dietary composition

T Esko, JN Hirschhorn, HA Feldman, YHH Hsu… - The American journal of …, 2017 - Elsevier
Background: Clinical nutrition research often lacks robust markers of compliance,
complicating the interpretation of clinical trials and observational studies of free-living …

[HTML][HTML] Modulation of the gut microbiota by resistant starch as a treatment of chronic kidney diseases: evidence of efficacy and mechanistic insights

M Snelson, NJ Kellow, MT Coughlan - Advances in nutrition, 2019 - Elsevier
Chronic kidney disease (CKD) has been associated with changes in gut microbial ecology,
or “dysbiosis,” which may contribute to disease progression. Recent studies have focused …

[HTML][HTML] Metabolomics and transcriptomics pathway approach reveals outcome-specific perturbations in COPD

CI Cruickshank-Quinn, S Jacobson, G Hughes… - Scientific reports, 2018 - nature.com
Chronic obstructive pulmonary disease (COPD) comprises multiple phenotypes such as
airflow obstruction, emphysema, and frequent episodes of acute worsening of respiratory …

The Influence of Animal- or Plant-Based Diets on Blood and Urine Trimethylamine-N-Oxide (TMAO) Levels in Humans

M Lombardo, G Aulisa, D Marcon, G Rizzo - Current Nutrition Reports, 2022 - Springer
Abstract Purpose of Review The aim of the review was to evaluate which diets are
associated with higher TMAO levels. Recent Findings Several studies have shown that …